| Literature DB >> 21467018 |
Tom C Darton1, James B Wing, Andrew Lees, Andrew W Heath, Robert C Read.
Abstract
Adults who have recovered from an episode of invasive pneumococcal disease demonstrate defective B cell activation in response to αδ-dex, a polyclonal polysaccharide mimic, compared with matched control subjects. The defect is not overcome by CD4(+) T cell assistance and may explain the relatively poor response to pneumococcal vaccination in survivors of invasive pneumococcal disease.Entities:
Mesh:
Substances:
Year: 2011 PMID: 21467018 PMCID: PMC3106266 DOI: 10.1093/cid/cir126
Source DB: PubMed Journal: Clin Infect Dis ISSN: 1058-4838 Impact factor: 9.079