| Literature DB >> 21466823 |
Hendrik Jan Thibaut1, Pieter Leyssen, Gerhard Puerstinger, Alexandra Muigg, Johan Neyts, Armando Mirko De Palma.
Abstract
We report here on a comparative study of the activity of 10 enterovirus inhibitors against poliovirus 1, enterovirus 71 and human rhinovirus 14. Three of the selected molecules (Pleconaril, BTA-798 and V-073) are in clinical development. The in vitro antiviral activity of pairwise combinations of inhibitors indicated that most combinations resulted in an additive to slightly synergistic antiviral activity. However, the combination of ribavirin with a nucleoside polymerase inhibitor resulted in a pronounced antagonistic effect.Entities:
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Year: 2011 PMID： 21466823 DOI： 10.1016/j.antiviral.2011.03.187
Source DB: PubMed Journal: Antiviral Res ISSN： 0166-3542 Impact factor: 5.970