| Literature DB >> 21464596 |
Doseung Lee1, Jin-Kyu Woo, Donghern Kim, Minyoung Kim, Somi K Cho, Jae Hoon Kim, Se Pill Park, Hyo Yeon Lee, Key Zung Riu, Dong-Sun Lee.
Abstract
Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an alpha-glucosidase inhibitor with an IC50 value of 10 micrometer. It showed mixedtype inhibition of alpha-glucosidase with a Ki value of 5.94 micrometer. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21464596
Source DB: PubMed Journal: J Microbiol Biotechnol ISSN： 1017-7825 Impact factor: 2.351