Literature DB >> 21463901

Late life depression and incident activity limitations: influence of gender and symptom severity.

Isabelle Carrière1, Laure Anne Gutierrez, Karine Pérès, Claudine Berr, Pascale Barberger-Gateau, Karen Ritchie, Marie Laure Ancelin.   

Abstract

BACKGROUND: Mental disorders, especially depression, are one of the principal causes of disablement. Previous research has been limited partly due to the failure to take into account sub-syndromal states and the very large number of candidate mediating and confounding factors.
METHODS: Longitudinal associations between baseline depressive symptomatology and activity limitations were examined in a community-dwelling elderly cohort of 3191 participants. Mixed logistic models were used to determine associations between mild or severe depressive symptoms (Center for Epidemiologic Studies-Depression Scale, CES-D), and 7-year incident disability on four limitation scales assessing instrumental and basic activities of daily living, mobility using the Rosow and Breslau scale, and social restriction.
RESULTS: In men, mild depressive symptomatology was associated with increased incident limitations on instrumental activities of daily living (IADL) (odds ratio (OR) (95% CI)=5.07 (2.25-11.42)). In women, severe depressive symptomatology was related to social restriction (OR (95% CI)=2.36 (1.31-4.25)), IADL (OR (95% CI)=1.89 (1.13-3.15)) and activities of daily living (OR (95% CI)=11.15 (3.43-36.23)). Men and women with a 2-year increase in CES-D score were highly at risk for social restriction and limitations in mobility and IADL.
CONCLUSION: Depression is an independent predictor of disability in the elderly population; the relation is gender-dependent and varies with symptom load.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID: 21463901     DOI: 10.1016/j.jad.2011.03.020

Source DB:  PubMed          Journal:  J Affect Disord        ISSN: 0165-0327            Impact factor:   4.839


  9 in total

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8.  Antidepressant use and cognitive decline in community-dwelling elderly people - The Three-City Cohort.

Authors:  Isabelle Carrière; Joanna Norton; Amandine Farré; Marilyn Wyart; Christophe Tzourio; Pernelle Noize; Karine Pérès; Annie Fourrier-Réglat; Karen Ritchie; Marie Laure Ancelin
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  9 in total

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