OBJECTIVE: Clear cell carcinoma (CCC) of the ovary is increasingly recognized as responding poorly to chemotherapy (CT). This review examines the outcomes achieved with a variety of CT regimens, looking for evidence of activity that might guide the development of more effective treatments. METHODS: A retrospective chart review of all cases of CCC referred to the BC Cancer Agency (BCCA) between 2000 and 2008 was conducted. Data were collected from those with primarily advanced disease and from those who recurred after adjuvant treatment. Outcomes were measured using broad definitions of treatment benefit (any objective or subjective evidence of disease control) in order to reflect the real-life use of palliative therapy. RESULTS: There were 158 women with pure CCC. First-line therapy for advanced disease was delivered to 33 patients. Second- and third-line treatment was delivered to 47 and 25 patients, respectively. The total number of treatment courses was 105: 88 CT-alone courses, 14 radiation therapy (RT)-alone and 3 combined modality. Treatment benefit was recorded in 24% of patients receiving CT, 64% of patients receiving RT, and each who received combined modality treatment. There was no CT drug class identified as obviously efficacious. CONCLUSION: Most patients with advanced or recurrent CCC have a low benefit-to-failure ratio from palliative CT. The role of RT and targeted agents must be explored to improve clinical outcomes for such patients.
OBJECTIVE:Clear cell carcinoma (CCC) of the ovary is increasingly recognized as responding poorly to chemotherapy (CT). This review examines the outcomes achieved with a variety of CT regimens, looking for evidence of activity that might guide the development of more effective treatments. METHODS: A retrospective chart review of all cases of CCC referred to the BC Cancer Agency (BCCA) between 2000 and 2008 was conducted. Data were collected from those with primarily advanced disease and from those who recurred after adjuvant treatment. Outcomes were measured using broad definitions of treatment benefit (any objective or subjective evidence of disease control) in order to reflect the real-life use of palliative therapy. RESULTS: There were 158 women with pure CCC. First-line therapy for advanced disease was delivered to 33 patients. Second- and third-line treatment was delivered to 47 and 25 patients, respectively. The total number of treatment courses was 105: 88 CT-alone courses, 14 radiation therapy (RT)-alone and 3 combined modality. Treatment benefit was recorded in 24% of patients receiving CT, 64% of patients receiving RT, and each who received combined modality treatment. There was no CT drug class identified as obviously efficacious. CONCLUSION: Most patients with advanced or recurrent CCC have a low benefit-to-failure ratio from palliative CT. The role of RT and targeted agents must be explored to improve clinical outcomes for such patients.
Authors: Sebastian Vaughan; Jermaine I Coward; Robert C Bast; Andy Berchuck; Jonathan S Berek; James D Brenton; George Coukos; Christopher C Crum; Ronny Drapkin; Dariush Etemadmoghadam; Michael Friedlander; Hani Gabra; Stan B Kaye; Chris J Lord; Ernst Lengyel; Douglas A Levine; Iain A McNeish; Usha Menon; Gordon B Mills; Kenneth P Nephew; Amit M Oza; Anil K Sood; Euan A Stronach; Henning Walczak; David D Bowtell; Frances R Balkwill Journal: Nat Rev Cancer Date: 2011-09-23 Impact factor: 60.716
Authors: Y He; A C Wu; B S Harrington; C M Davies; S J Wallace; M N Adams; J S Palmer; D K Roche; B G Hollier; T F Westbrook; H Hamidi; G E Konecny; B Winterhoff; N P Chetty; A J Crandon; N B Oliveira; C M Shannon; A V Tinker; C B Gilks; J I Coward; J W Lumley; L C Perrin; J E Armes; J D Hooper Journal: Oncogene Date: 2015-04-20 Impact factor: 9.867
Authors: Meng Xu-Welliver; William T C Yuh; Julia R Fielding; Katarzyna J Macura; Zhibin Huang; Ahmet S Ayan; Floor J Backes; Guang Jia; Mariam Moshiri; Jun Zhang; Nina A Mayr Journal: Radiographics Date: 2014 Jul-Aug Impact factor: 5.333
Authors: Kate E Oliver; William E Brady; Michael Birrer; David M Gershenson; Gini Fleming; Larry J Copeland; Krishnansu Tewari; Peter A Argenta; Robert S Mannel; Angeles Alvarez Secord; Jean-Marie Stephan; David G Mutch; Frederick B Stehman; Franco M Muggia; Peter G Rose; Deborah K Armstrong; Michael A Bookman; Robert A Burger; John H Farley Journal: Gynecol Oncol Date: 2017-08-12 Impact factor: 5.482
Authors: Tashbib Khan; Yaowu He; Thomas Kryza; Brittney S Harrington; Jennifer H Gunter; Mitchell A Sullivan; Tahleesa Cuda; Rebecca Rogers; Claire M Davies; Amy Broomfield; Madeline Gough; Andy C Wu; Thomas McGann; S John Weroha; Paul Haluska; Josephine M Forbes; Jane E Armes; Sinead C Barry; Jermaine I Coward; Nisha Jagasia; Naven Chetty; Cameron E Snell; Rohan Lourie; Lewis C Perrin; John D Hooper Journal: Cancers (Basel) Date: 2020-04-03 Impact factor: 6.639