BACKGROUND: Protein supplements are routinely used after a laparoscopic gastric bypass (LGB). The aim of this study was to evaluate the impact of an amino acid supplement on glucose homeostasis and hormonal and inflammatory markers after LGB. STUDY DESIGN:Thirty patients undergoing LGB were randomized to receive or not 24 g of an oral supplement containing a leucine metabolite, glutamine, and arginine twice daily. Changes in weight, glucose, insulin, C-peptide, insulin sensitivity, interleukin (IL) 6, C-reactive protein (CRP), leptin, insulin-like growth factor (IGF) 1, ghrelin, and incretins were assessed preoperatively and 2 weeks and 8 weeks postoperatively. RESULTS:Thirty patients (96.7% female, age 46.9± 8.4 years, body mass index 43.3 ± 4.1 kg/m(2)) were randomized. The experimental (n = 14) and control (n = 16) groups were not significantly different at baseline. Weight loss was similar for the 2 groups. Fasting glucose decreased significantly at 2 and 8 weeks compared with base line (p < 0.0001) with no difference between the experimental and control groups (p = 0.8), but insulin and calculated insulin sensitivity, which were similar at baseline, became significantly worse in the experimental group 8 weeks after surgery (p = 0.02 for insulin; p = 0.04 for the homeostasis model assessment of insulin resistance). CRP and IL-6, which were similar at baseline, were found to be significantly higher at 8 weeks in the experimental group (p = 0.018 and p = 0.05, respectively). Leptin and IGF-1 levels decreased significantly from baseline at 2 and 8 weeks (p < 0.0001), but there was no difference between the 2 groups. No significant changes in GLP-1, ghrelin, or gastric inhibitory polypeptide were noticed after 8 weeks. CONCLUSIONS: An amino acid supplement had no effect on the early postoperative incretins after LGB. It may have a negative influence on glucose kinetics and degree of inflammation. Future studies are needed to clarify these effects.
RCT Entities:
BACKGROUND: Protein supplements are routinely used after a laparoscopic gastric bypass (LGB). The aim of this study was to evaluate the impact of an amino acid supplement on glucose homeostasis and hormonal and inflammatory markers after LGB. STUDY DESIGN: Thirty patients undergoing LGB were randomized to receive or not 24 g of an oral supplement containing a leucine metabolite, glutamine, and arginine twice daily. Changes in weight, glucose, insulin, C-peptide, insulin sensitivity, interleukin (IL) 6, C-reactive protein (CRP), leptin, insulin-like growth factor (IGF) 1, ghrelin, and incretins were assessed preoperatively and 2 weeks and 8 weeks postoperatively. RESULTS: Thirty patients (96.7% female, age 46.9 ± 8.4 years, body mass index 43.3 ± 4.1 kg/m(2)) were randomized. The experimental (n = 14) and control (n = 16) groups were not significantly different at baseline. Weight loss was similar for the 2 groups. Fasting glucose decreased significantly at 2 and 8 weeks compared with base line (p < 0.0001) with no difference between the experimental and control groups (p = 0.8), but insulin and calculated insulin sensitivity, which were similar at baseline, became significantly worse in the experimental group 8 weeks after surgery (p = 0.02 for insulin; p = 0.04 for the homeostasis model assessment of insulin resistance). CRP and IL-6, which were similar at baseline, were found to be significantly higher at 8 weeks in the experimental group (p = 0.018 and p = 0.05, respectively). Leptin and IGF-1 levels decreased significantly from baseline at 2 and 8 weeks (p < 0.0001), but there was no difference between the 2 groups. No significant changes in GLP-1, ghrelin, or gastric inhibitory polypeptide were noticed after 8 weeks. CONCLUSIONS: An amino acid supplement had no effect on the early postoperative incretins after LGB. It may have a negative influence on glucose kinetics and degree of inflammation. Future studies are needed to clarify these effects.
Authors: Christopher J Lynch; Beth Gern; Carolyn Lloyd; Susan M Hutson; Rachel Eicher; Thomas C Vary Journal: Am J Physiol Endocrinol Metab Date: 2006-04-25 Impact factor: 4.310
Authors: Luis Alberto Vázquez; Fernando Pazos; José Ramón Berrazueta; Carlos Fernández-Escalante; María Teresa García-Unzueta; Julio Freijanes; José Antonio Amado Journal: J Clin Endocrinol Metab Date: 2004-10-26 Impact factor: 5.958
Authors: Daniela Cota; Karine Proulx; Kathi A Blake Smith; Sara C Kozma; George Thomas; Stephen C Woods; Randy J Seeley Journal: Science Date: 2006-05-12 Impact factor: 47.728
Authors: J Salas-Salvadó; M Bulló; P García-Lorda; R Figueredo; D Del Castillo; A Bonada; R Balanzà Journal: Int J Obes (Lond) Date: 2006-04-25 Impact factor: 5.095
Authors: Jamie I Baum; Jason C O'Connor; Jennifer E Seyler; Tracy G Anthony; Gregory G Freund; Donald K Layman Journal: Am J Physiol Endocrinol Metab Date: 2004-08-31 Impact factor: 4.310
Authors: Robyn A Tamboli; Joseph Antoun; Reem M Sidani; Austin Clements; Emily E Harmata; Pam Marks-Shulman; Bruce D Gaylinn; Brandon Williams; Ronald H Clements; Vance L Albaugh; Naji N Abumrad Journal: Diabetes Obes Metab Date: 2017-05-31 Impact factor: 6.577
Authors: Tharsus Dias Takeuti; Guilherme Azevedo Terra; Alex Augusto da Silva; Júverson Alves Terra; Luci Mara da Silva; Eduardo Crema Journal: Arq Bras Cir Dig Date: 2014
Authors: Keliane Liberman; Rose Njemini; Yvette Luiking; Louis N Forti; Sjors Verlaan; Jürgen M Bauer; Robert Memelink; Kirsten Brandt; Lorenzo M Donini; Marcello Maggio; Tony Mets; Sander L J Wijers; Cornel Sieber; Tommy Cederholm; Ivan Bautmans Journal: Aging Clin Exp Res Date: 2019-05-02 Impact factor: 3.636
Authors: Julia Lischka; Andrea Schanzer; Azadeh Hojreh; Ahmed Ba Ssalamah; Chike Bellarmine Item; Charlotte de Gier; Nina-Katharina Walleczek; Thomas F Metz; Ivana Jakober; Susanne Greber-Platzer; Maximilian Zeyda Journal: Pediatr Obes Date: 2020-10-14 Impact factor: 4.000