| Literature DB >> 21462960 |
Milica Jaric1, Benjamin A Haag, Sophia M Manolikakes, Paul Knochel.
Abstract
Quinine, nicotine, and related electron-rich amino-substituted pyridines were readily metalated using LiCl-solubilized TMP (2,2,6,6-tetramethylpiperidyl) bases in the presence of BF(3)·OEt(2). A full pyridine functionalization of all five positions of the pyridine ring can be realized by using an appropriate combination of TMP bases in the presence or absence of BF(3)·OEt(2).Entities:
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Year: 2011 PMID： 21462960 DOI： 10.1021/ol200563j
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005