K Herkommer1, C Schmidt, J E Gschwend. 1. Urologische Klinik, Klinikum rechts der Isar der TU München, Ismaningerstraße 22, 81675 München, Deutschland. kathleen.herkommer@lrz.tum.de
Abstract
BACKGROUND: The German national research project"familial prostate cancer" has been recruiting prostate cancer patients nationwide since 1999. In 2009, a comprehensive data analysis of the 25,065 families recruited was performed. Of these, 77.4% were identified as sporadic, 20.0% as familial and 2.6% as hereditary cases of prostate cancer. However, obtaining comprehensive, validated information about all relatives often fails. RESULTS: The high average age of the patients, the lower life expectancy in further generations and the low number of first-degree male relatives hampers the classification of sporadic, familial and hereditary cases. Consequently we describe here that in our database the identification of 100 hereditary cases requires a recruitment of more than 5,000 patients with their families. For 100 sporadic patients with 2 first-degree male relatives without a case history 1,250 patients are needed.
BACKGROUND: The German national research project"familial prostate cancer" has been recruiting prostate cancerpatients nationwide since 1999. In 2009, a comprehensive data analysis of the 25,065 families recruited was performed. Of these, 77.4% were identified as sporadic, 20.0% as familial and 2.6% as hereditary cases of prostate cancer. However, obtaining comprehensive, validated information about all relatives often fails. RESULTS: The high average age of the patients, the lower life expectancy in further generations and the low number of first-degree male relatives hampers the classification of sporadic, familial and hereditary cases. Consequently we describe here that in our database the identification of 100 hereditary cases requires a recruitment of more than 5,000 patients with their families. For 100 sporadic patients with 2 first-degree male relatives without a case history 1,250 patients are needed.
Authors: Rosemarie Plaetke; Ian Thompson; Michael Sarosdy; J M Harris; Dean Troyer; Nedal H Arar Journal: Urol Oncol Date: 2002 Jan-Feb Impact factor: 3.498
Authors: A Valeri; R Azzouzi; E Drelon; A Delannoy; P Mangin; G Fournier; P Berthon; O Cussenot Journal: Prostate Date: 2000-09-15 Impact factor: 4.104
Authors: Robert J MacInnis; Antonis C Antoniou; Rosalind A Eeles; Gianluca Severi; Michelle Guy; Lesley McGuffog; Amanda L Hall; Lynne T O'Brien; Rosemary A Wilkinson; David P Dearnaley; Audrey T Ardern-Jones; Alan Horwich; Vincent S Khoo; Christopher C Parker; Robert A Huddart; Margaret R McCredie; Charmaine Smith; Melissa C Southey; Margaret P Staples; Dallas R English; John L Hopper; Graham G Giles; Douglas F Easton Journal: Genet Epidemiol Date: 2010-01 Impact factor: 2.135
Authors: Andreas Dinkel; Marielouise Kornmayer; Jürgen E Gschwend; Birgitt Marten-Mittag; Peter Herschbach; Kathleen Herkommer Journal: Fam Cancer Date: 2014-09 Impact factor: 2.375
Authors: Mark Thalgott; Martina Kron; Johannes M Brath; Donna P Ankerst; Ian M Thompson; Juergen E Gschwend; Kathleen Herkommer Journal: World J Urol Date: 2017-11-21 Impact factor: 4.226