BACKGROUND: A crucial early event in polycyclic aromatic hydrocarbons (PAHs) carcinogenesis is the induction of genomic instability phenotype that initiates the progression of a proliferative cell into a cancer cell. However, epidemiological results have been inconsistent. OBJECTIVES: To assess reported studies of associations between the levels of chromosomal damage including sister chromatid exchange (SCE), chromosomal aberrations (CA), and cytokinesis-block micronucleus (CBMN) in peripheral blood lymphocytes and occupational exposure to PAHs. METHODS: Meta-analysis on the association between chromosomal damage and occupational exposure to PAHs was performed with STATA 10.0 software package and Review Manager 4.2.10 in this study. RESULTS: We found statistically significant differences in the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes between PAHs-exposed group and control group, and the summary estimates of weighted mean difference were 1.42 (95% CI: 0.82-2.02), 1.22 (95% CI: 0.33-2.10), and 0.96 (95% CI: 0.37-1.56), respectively. CONCLUSIONS: Data indicate that the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes might be indicators of early genetic effects for occupationally PAHs-exposed population.
BACKGROUND: A crucial early event in polycyclic aromatic hydrocarbons (PAHs) carcinogenesis is the induction of genomic instability phenotype that initiates the progression of a proliferative cell into a cancer cell. However, epidemiological results have been inconsistent. OBJECTIVES: To assess reported studies of associations between the levels of chromosomal damage including sister chromatid exchange (SCE), chromosomal aberrations (CA), and cytokinesis-block micronucleus (CBMN) in peripheral blood lymphocytes and occupational exposure to PAHs. METHODS: Meta-analysis on the association between chromosomal damage and occupational exposure to PAHs was performed with STATA 10.0 software package and Review Manager 4.2.10 in this study. RESULTS: We found statistically significant differences in the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes between PAHs-exposed group and control group, and the summary estimates of weighted mean difference were 1.42 (95% CI: 0.82-2.02), 1.22 (95% CI: 0.33-2.10), and 0.96 (95% CI: 0.37-1.56), respectively. CONCLUSIONS: Data indicate that the frequencies of SCE, CBMN, and CA (aberrations per 100 cells) in peripheral blood lymphocytes might be indicators of early genetic effects for occupationally PAHs-exposed population.
Authors: J H van Delft; M S Steenwinkel; J G van Asten; N de Vogel; T C Bruijntjes-Rozier; T Schouten; P Cramers; L Maas; M H van Herwijnen; F van Schooten; P M Hopmans Journal: Ann Occup Hyg Date: 2001-07
Authors: S Bonassi; C Bolognesi; A Abbondandolo; R Barale; P Bigatti; L Camurri; L Dalpra; M De Ferrari; A Forni; C Lando Journal: Cancer Epidemiol Biomarkers Prev Date: 1995-09 Impact factor: 4.254
Authors: W Popp; C Vahrenholz; C Schell; G Grimmer; G Dettbarn; R Kraus; A Brauksiepe; B Schmeling; T Gutzeit; J von Bülow; K Norpoth Journal: Occup Environ Med Date: 1997-03 Impact factor: 4.402