Literature DB >> 21461719

How to cross immunogenetic hurdles to human embryonic stem cell transplantation.

Casimir de Rham1, Jean Villard.   

Abstract

Implantation of human embryonic stem cells (hES), derived progenitors or mature cells derived from hES has great therapeutic potential for many diseases. If hES would come from genetically unrelated individuals, it would be probably rejected by the immune system of the recipient. Blood groups, MHC and minor antigens are the immunogenetic hurdles that have to be crossed for successful transplantation. Autologous transplantation with adult stem cells would be the best approach but several elements argue against this option. Classical immunosuppression, depleting antibody, induction of tolerance and stem cell banking are alternative methods that could be proposed to limit the risk of rejection.

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Year:  2011        PMID： 21461719     DOI： 10.1007/s00281-011-0262-z

Source DB:  PubMed          Journal:  Semin Immunopathol        ISSN： 1863-2297            Impact factor:   9.623


  52 in total

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  7 in total

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