Literature DB >> 21459008

High-power liquid-lithium target prototype for accelerator-based boron neutron capture therapy.

S Halfon1, M Paul, A Arenshtam, D Berkovits, M Bisyakoev, I Eliyahu, G Feinberg, N Hazenshprung, D Kijel, A Nagler, I Silverman.   

Abstract

A prototype of a compact Liquid-Lithium Target (LiLiT), which will possibly constitute an accelerator-based intense neutron source for Boron Neutron Capture Therapy (BNCT) in hospitals, was built. The LiLiT setup is presently being commissioned at Soreq Nuclear Research Center (SNRC). The liquid-lithium target will produce neutrons through the (7)Li(p,n)(7)Be reaction and it will overcome the major problem of removing the thermal power generated using a high-intensity proton beam (>10 kW), necessary for sufficient neutron flux. In off-line circulation tests, the liquid-lithium loop generated a stable lithium jet at high velocity, on a concave supporting wall; the concept will first be tested using a high-power electron beam impinging on the lithium jet. High intensity proton beam irradiation (1.91-2.5 MeV, 2-4 mA) will take place at Soreq Applied Research Accelerator Facility (SARAF) superconducting linear accelerator currently in construction at SNRC. Radiological risks due to the (7)Be produced in the reaction were studied and will be handled through a proper design, including a cold trap and appropriate shielding. A moderator/reflector assembly is planned according to a Monte Carlo simulation, to create a neutron spectrum and intensity maximally effective to the treatment and to reduce prompt gamma radiation dose risks. Copyright Â
© 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID: 21459008     DOI: 10.1016/j.apradiso.2011.03.016

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN: 0969-8043            Impact factor:   1.513


  3 in total

1.  Present status of Accelerator-Based BNCT.

Authors:  Andres Juan Kreiner; Javier Bergueiro; Daniel Cartelli; Matias Baldo; Walter Castell; Javier Gomez Asoia; Javier Padulo; Juan Carlos Suárez Sandín; Marcelo Igarzabal; Julian Erhardt; Daniel Mercuri; Alejandro A Valda; Daniel M Minsky; Mario E Debray; Hector R Somacal; María Eugenia Capoulat; María S Herrera; Mariela F Del Grosso; Leonardo Gagetti; Manuel Suarez Anzorena; Nicolas Canepa; Nicolas Real; Marcelo Gun; Hernán Tacca
Journal:  Rep Pract Oncol Radiother       Date:  2014-12-12

2.  Radiobiological response of U251MG, CHO-K1 and V79 cell lines to accelerator-based boron neutron capture therapy.

Authors:  Eisuke Sato; Alexander Zaboronok; Tetsuya Yamamoto; Kei Nakai; Sergey Taskaev; Olga Volkova; Ludmila Mechetina; Alexander Taranin; Vladimir Kanygin; Tomonori Isobe; Bryan J Mathis; Akira Matsumura
Journal:  J Radiat Res       Date:  2018-03-01       Impact factor: 2.724

3.  A Novel Approach to Design and Evaluate BNCT Neutron Beams Combining Physical, Radiobiological, and Dosimetric Figures of Merit.

Authors:  Ian Postuma; Sara González; Maria S Herrera; Lucas Provenzano; Michele Ferrarini; Chiara Magni; Nicoletta Protti; Setareh Fatemi; Valerio Vercesi; Giuseppe Battistoni; Umberto Anselmi Tamburini; Yuan Hao Liu; Leena Kankaanranta; Hanna Koivunoro; Saverio Altieri; Silva Bortolussi
Journal:  Biology (Basel)       Date:  2021-02-26
  3 in total

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