OBJECTIVES: To identify systemically detectable vascular inflammation associated to redox system unbalance, advanced oxidation protein products (AOPP), formed by HClO reaction with proteins, Thiol levels, and their ratio (AOPP/Thiol ratio) were measured in patients with acute coronary syndromes (ACS). DESIGN AND METHODS: We evaluated AOPP/Thiol ratio together with CRP and IL-1β in 18 acute myocardial infarction (AMI) and in 16 unstable angina (UA) patients at admission, and in 16 control subjects (CTR); the measurements were repeated at 1 and at 6 months. RESULTS: At admission, AMI and UA patients displayed higher AOPP/Thiol ratio and CRP and IL-1β compared to CTR subjects. A correlation between AOPP/Thiols and IL-1β in AMI was found. At follow-up, in UA only, AOPP/Thiol ratio and IL-1β levels still remained high. CONCLUSIONS: The AOPP/Thiol ratio seems to affect the inflammatory process in ACS, and may represent a reliable marker of oxidative unbalance in this setting of patients.
OBJECTIVES: To identify systemically detectable vascular inflammation associated to redox system unbalance, advanced oxidation protein products (AOPP), formed by HClO reaction with proteins, Thiol levels, and their ratio (AOPP/Thiol ratio) were measured in patients with acute coronary syndromes (ACS). DESIGN AND METHODS: We evaluated AOPP/Thiol ratio together with CRP and IL-1β in 18 acute myocardial infarction (AMI) and in 16 unstable angina (UA) patients at admission, and in 16 control subjects (CTR); the measurements were repeated at 1 and at 6 months. RESULTS: At admission, AMI and UA patients displayed higher AOPP/Thiol ratio and CRP and IL-1β compared to CTR subjects. A correlation between AOPP/Thiols and IL-1β in AMI was found. At follow-up, in UA only, AOPP/Thiol ratio and IL-1β levels still remained high. CONCLUSIONS: The AOPP/Thiol ratio seems to affect the inflammatory process in ACS, and may represent a reliable marker of oxidative unbalance in this setting of patients.
Authors: Débora Coimbra-Costa; Fernando Garzón; Norma Alva; Tiago C C Pinto; Fernando Aguado; Joan Ramon Torrella; Teresa Carbonell; Ramón Rama Journal: Int J Mol Sci Date: 2021-05-17 Impact factor: 5.923
Authors: Seun Deuk Hwang; Yoon Ji Kim; Sang Heun Lee; Deok Kyu Cho; Yun Hyeong Cho; Sung Jin Moon; Sang Choel Lee; Soo Young Yoon Journal: Yonsei Med J Date: 2013-11 Impact factor: 2.759