Literature DB >> 2145836

Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte.

T Seki1, I Ihara, A Sugimura, M Shimonishi, T Nishizawa, O Asami, M Hagiya, T Nakamura, S Shimizu.   

Abstract

Human leukocyte cDNA library was screened to isolate cDNA clones coding for hepatocyte growth factor using cDNA from human liver as a probe. Nucleotide and deduced amino acid sequences were analyzed for two of four clones obtained. One of them contained an open reading frame coding for a polypeptide chain of 728 amino acid residues like that of cDNA clone derived from human liver. In another clone a spontaneous deletion of 15 base pairs was found within the coding sequence. When expressed transiently using COS-1 cells both clones produced protein with similar biological activity against rat hepatocyte in vitro.

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Year:  1990        PMID： 2145836     DOI： 10.1016/s0006-291x(05)80212-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  32 in total

1.  Hepatocyte growth factor.

Authors:  A J Strain; J M Neuberger
Journal:  Gut       Date:  1992-02       Impact factor: 23.059

2.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-06-25       Impact factor: 16.971

3.  Hepatocyte growth factor and transforming growth factor beta regulate 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene expression in rat hepatocyte primary cultures.

Authors:  M Joaquin; J L Rosa; C Salvadó; S López; T Nakamura; R Bartrons; J Gil; A Tauler
Journal:  Biochem J       Date:  1996-02-15       Impact factor: 3.857

4.  Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis.

Authors:  Wook-Hwan Kim; Kunio Matsumoto; Kazuhiko Bessho; Toshikazu Nakamura
Journal:  Am J Pathol       Date:  2005-04       Impact factor: 4.307

5.  Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride.

Authors:  J J Maher
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

6.  Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice.

Authors:  K Kawaida; K Matsumoto; H Shimazu; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1994-05-10       Impact factor: 11.205

7.  Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA.

Authors:  W M Mars; R Zarnegar; G K Michalopoulos
Journal:  Am J Pathol       Date:  1993-09       Impact factor: 4.307

8.  Identification and characterization of "injurin," an inducer of expression of the gene for hepatocyte growth factor.

Authors:  K Matsumoto; H Tajima; M Hamanoue; S Kohno; T Kinoshita; T Nakamura
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205

9.  A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis.

Authors:  G Hartmann; L Naldini; K M Weidner; M Sachs; E Vigna; P M Comoglio; W Birchmeier
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-01       Impact factor: 11.205

10.  Hepatocyte growth factor and macrophage inflammatory protein 1 beta: structurally distinct cytokines that induce rapid cytoskeletal changes and subset-preferential migration in T cells.

Authors:  D H Adams; L Harvath; D P Bottaro; R Interrante; G Catalano; Y Tanaka; A Strain; S G Hubscher; S Shaw
Journal:  Proc Natl Acad Sci U S A       Date:  1994-07-19       Impact factor: 11.205
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