Literature DB >> 21457141

In silico identification of microRNAs predicted to regulate the drug metabolizing cytochrome P450 genes.

Anuradha Ramamoorthy1, Todd C Skaar.   

Abstract

OBJECTIVE: Cytochrome P450 (CYP) enzymes exhibit high interindividual variability that is not completely explained by known environmental and genetic factors. To further understand this variability, we hypothesized that microRNAs (miRNAs) may regulate CYP expression.
METHODS: MiRNA identification algorithms were used to identify the miRNAs that are predicted to regulate twelve major drug metabolizing CYPs and to identify polymorphisms in CYP mRNA 3'-UTRs that are predicted to interfere with normal mRNA-miRNA interactions.
RESULTS: All twelve CYPs were predicted to be targets of miRNAs. Additionally, 38 SNPs in CYP mRNA 3'-UTRs were predicted to interfere with miRNA targeting of mRNAs. These predicted miRNAs and SNPs are candidates for future in vitro studies focused on understanding the molecular regulation of these CYP genes.
CONCLUSION: These in silico results provide strong support for a role of miRNA in the regulation and variability of CYP expression. ©2011 Bentham Science Publishers Ltd.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21457141      PMCID： PMC4308728          DOI： 10.2174/187231211795305258

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN： 1872-3128


  25 in total

1.  A uniform system for microRNA annotation.

Authors:  Victor Ambros; Bonnie Bartel; David P Bartel; Christopher B Burge; James C Carrington; Xuemei Chen; Gideon Dreyfuss; Sean R Eddy; Sam Griffiths-Jones; Mhairi Marshall; Marjori Matzke; Gary Ruvkun; Thomas Tuschl
Journal:  RNA       Date:  2003-03       Impact factor: 4.942

2.  Rifampin is a selective, pleiotropic inducer of drug metabolism genes in human hepatocytes: studies with cDNA and oligonucleotide expression arrays.

Authors:  J M Rae; M D Johnson; M E Lippman; D A Flockhart
Journal:  J Pharmacol Exp Ther       Date:  2001-12       Impact factor: 4.030

3.  Human CYP2E1 is regulated by miR-378.

Authors:  Takuya Mohri; Miki Nakajima; Tatsuki Fukami; Masataka Takamiya; Yasuhiro Aoki; Tsuyoshi Yokoi
Journal:  Biochem Pharmacol       Date:  2009-11-27       Impact factor: 5.858

4.  Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.

Authors:  Kenneth K W To; Zhirong Zhan; Thomas Litman; Susan E Bates
Journal:  Mol Cell Biol       Date:  2008-06-23       Impact factor: 4.272

5.  MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translation.

Authors:  Ulf Andersson Ørom; Finn Cilius Nielsen; Anders H Lund
Journal:  Mol Cell       Date:  2008-05-23       Impact factor: 17.970

Review 6.  Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants.

Authors:  David R Nelson; Darryl C Zeldin; Susan M G Hoffman; Lois J Maltais; Hester M Wain; Daniel W Nebert
Journal:  Pharmacogenetics       Date:  2004-01

7.  MicroRNA-373 induces expression of genes with complementary promoter sequences.

Authors:  Robert F Place; Long-Cheng Li; Deepa Pookot; Emily J Noonan; Rajvir Dahiya
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-28       Impact factor: 11.205

8.  MicroRNAs regulate CYP3A4 expression via direct and indirect targeting.

Authors:  Yu-Zhuo Pan; Wenqing Gao; Ai-Ming Yu
Journal:  Drug Metab Dispos       Date:  2009-07-06       Impact factor: 3.922

9.  Prediction of mammalian microRNA targets.

Authors:  Benjamin P Lewis; I-hung Shih; Matthew W Jones-Rhoades; David P Bartel; Christopher B Burge
Journal:  Cell       Date:  2003-12-26       Impact factor: 41.582

10.  Post-transcriptional regulation of human pregnane X receptor by micro-RNA affects the expression of cytochrome P450 3A4.

Authors:  Shingo Takagi; Miki Nakajima; Takuya Mohri; Tsuyoshi Yokoi
Journal:  J Biol Chem       Date:  2008-02-11       Impact factor: 5.157
View more
  18 in total

1.  The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p.

Authors:  Yinting Chen; Linjuan Zeng; Yong Wang; William H Tolleson; Bridgett Knox; Si Chen; Zhen Ren; Lei Guo; Nan Mei; Feng Qian; Kaihong Huang; David Liu; Weida Tong; Dianke Yu; Baitang Ning
Journal:  Biochem Pharmacol       Date:  2017-08-16       Impact factor: 5.858

2.  In silico and in vitro identification of microRNAs that regulate hepatic nuclear factor 4α expression.

Authors:  Anuradha Ramamoorthy; Lang Li; Andrea Gaedigk; L DiAnne Bradford; Eric A Benson; David A Flockhart; Todd C Skaar
Journal:  Drug Metab Dispos       Date:  2012-01-09       Impact factor: 3.922

3.  Regulation of microRNA expression by rifampin in human hepatocytes.

Authors:  Anuradha Ramamoorthy; Yunlong Liu; Santosh Philips; Zeruesenay Desta; Hai Lin; Chirayu Goswami; Andrea Gaedigk; Lang Li; David A Flockhart; Todd C Skaar
Journal:  Drug Metab Dispos       Date:  2013-08-09       Impact factor: 3.922

4.  microRNA-34a is associated with expression of key hepatic transcription factors and cytochromes P450.

Authors:  V Lamba; Y Ghodke; W Guan; T S Tracy
Journal:  Biochem Biophys Res Commun       Date:  2014-02-12       Impact factor: 3.575

5.  Multiple genetic factors affecting the pharmacokinetic and pharmacodynamic processes of tacrolimus in Chinese myasthenia gravis patients.

Authors:  Huan-Yu Meng; Xi Li; Wan-Lin Jin; Cheng-Kai Yan; Xiao-Hua Dong; Qiu Xu; Yu-Yao Peng; Zhi-Bin Li; Yi Li; Zhao-Hui Luo; Li-Qun Xu; Huan Yang
Journal:  Eur J Clin Pharmacol       Date:  2020-01-18       Impact factor: 2.953

6.  Age-Related Changes in MicroRNA Expression and Pharmacogenes in Human Liver.

Authors:  K S Burgess; S Philips; E A Benson; Z Desta; A Gaedigk; R Gaedigk; M W Segar; Y Liu; T C Skaar
Journal:  Clin Pharmacol Ther       Date:  2015-08       Impact factor: 6.875

7.  Relationship between differential hepatic microRNA expression and decreased hepatic cytochrome P450 3A activity in cirrhosis.

Authors:  Raj Vuppalanchi; Tiebing Liang; Chirayu Pankaj Goswami; Rohit Nalamasu; Lang Li; David Jones; Rongrong Wei; Wanqing Liu; Vishal Sarasani; Sarath Chandra Janga; Naga Chalasani
Journal:  PLoS One       Date:  2013-09-13       Impact factor: 3.240

8.  Genetic variation in the 3'-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2, and UGT2B7: potential effects on regulation by microRNA and pharmacogenomics relevance.

Authors:  Marelize Swart; Collet Dandara
Journal:  Front Genet       Date:  2014-06-04       Impact factor: 4.599

9.  MicroRNA regulation of CYP 1A2, CYP3A4 and CYP2E1 expression in acetaminophen toxicity.

Authors:  Pritmohinder Gill; Sudeepa Bhattacharyya; Sandra McCullough; Lynda Letzig; Prasun J Mishra; Chunqiao Luo; Harsh Dweep; Laura James
Journal:  Sci Rep       Date:  2017-09-26       Impact factor: 4.379

10.  Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19.

Authors:  Nuala Ann Helsby; Kathryn Elisa Burns
Journal:  Front Genet       Date:  2012-10-10       Impact factor: 4.599
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.