| Literature DB >> 2145692 |
R Fernandez-Durango1, A Triviño, J M Ramirez, M Garcia de Lacoba, A Ramirez, J J Salazar, A Fernandez-Cruz, J Gutkowska.
Abstract
Atrial natriuretic factor (ANF) concentration in the aqueous humor (AH) was studied in rabbits with experimental glaucoma induced by injecting alpha-chymotrypsin into the posterior chamber. In normal rabbit eyes, the ANF concentration in AH was 3.1 +/- 1.2 pg/ml (mean +/- SEM; n = 12), ranging from 0 to 5.8 pg/ml, whereas it was significantly higher in AH from glaucomatous rabbit eyes, being 81.0 +/- 9.8 pg/ml (n = 12). These findings were correlated with intraocular pressure (IOP), which was 13.0 +/- 2.4 mmHg (n = 12) in normal rabbit eyes and significantly greater in glaucomatous eyes: 24.4 +/- 3.0 mmHg (n = 12). Our data indicate that enhanced ANF release in AH during experimental glaucoma may play an important physiological role in modulating IOP.Entities:
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Year: 1990 PMID： 2145692 DOI： 10.1016/0042-6989(90)90004-5
Source DB: PubMed Journal: Vision Res ISSN： 0042-6989 Impact factor: 1.886