| Literature DB >> 21456623 |
Daniel R Chancellor1, Kay E Davies, Olivier De Moor, Colin R Dorgan, Peter D Johnson, Adam G Lambert, Daniel Lawrence, Cristina Lecci, Carole Maillol, Penny J Middleton, Gary Nugent, Séverine D Poignant, Allyson C Potter, Paul D Price, Richard J Pye, Richard Storer, Jonathon M Tinsley, Renate van Well, Richard Vickers, Julia Vile, Fraser J Wilkes, Francis X Wilson, Stephen P Wren, Graham M Wynne.
Abstract
A series of novel 2-arylbenzoxazoles that upregulate the production of utrophin in murine H2K cells, as assessed using a luciferase reporter linked assay, have been identified. This compound class appears to hold considerable promise as a potential treatment for Duchenne muscular dystrophy. Following the delineation of structure-activity relationships in the series, a number of potent upregulators were identified, and preliminary ADME evaluation is described. These studies have resulted in the identification of 1, a compound that has been progressed to clinical trials.Entities:
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Year: 2011 PMID： 21456623 DOI： 10.1021/jm200135z
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446