| Literature DB >> 21456515 |
E Zachary Oblak1, Narendran G-Dayanandan, Dennis L Wright.
Abstract
A rapid approach to the spirocyclic core of cyclopamine was achieved in four steps from 2-pentenyl-furan. A furan Diels-Alder reaction followed by a one-pot dehalogenation/amination sequence provides the oxabicyclic triene that upon treatment with Grubbs' catalyst undergoes smooth rearrangement to the tricyclic core.Entities:
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Year: 2011 PMID： 21456515 DOI： 10.1021/ol200706f
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005