Literature DB >> 21455816

Cytochrome P450 2E1 and hyperglycemia-induced liver injury.

Aparajita Dey1, S Mathan Kumar.   

Abstract

Cytochrome P450 2E1 (CYP2E1), a microsomal enzyme involved in xenobiotic metabolism and generation of oxidative stress, has been implicated in promoting liver injury. The review deals with the changes in various cellular pathways in liver linked with the changes in regulation of CYP2E1 under hyperglycemic conditions. Some of the hepatic abnormalities associated with hyperglycemia-mediated induction of CYP2E1 include increased oxidative stress, changes in mitochondrial structure and function, apoptosis, nitrosative stress, and increased ketone body accumulation. Thus, changes in regulation of CYP2E1 are associated with the injurious effects of hyperglycemia in liver.

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Year:  2011        PMID： 21455816     DOI： 10.1007/s10565-011-9188-4

Source DB:  PubMed          Journal:  Cell Biol Toxicol        ISSN： 0742-2091            Impact factor:   6.691


  7 in total

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Journal:  J Physiol Sci       Date:  2011-11-29       Impact factor: 2.781

Review 2.  The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system.

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4.  Physiologically Based Pharmacokinetic (PBPK) Modeling of Metabolic Pathways of Bromochloromethane in Rats.

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Journal:  J Toxicol       Date:  2012-04-11

5.  Protective Effect of Pomegranate (Punica granatum) Extract against Diabetic Changes in Adult Male Rat Liver: Histological Study.

Authors:  Khadija A Faddladdeen; Ahlam Abdulaziz Ojaimi
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6.  Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health.

Authors:  Bahare Salehi; Laura Machin; Lianet Monzote; Javad Sharifi-Rad; Shahira M Ezzat; Mohamed A Salem; Rana M Merghany; Nihal M El Mahdy; Ceyda Sibel Kılıç; Oksana Sytar; Mehdi Sharifi-Rad; Farukh Sharopov; Natália Martins; Miquel Martorell; William C Cho
Journal:  ACS Omega       Date:  2020-05-14

7.  Treatment with omega-3 PUFAs does not increase the risk of CYP2E1-dependent oxidative stress and diabetic liver pathology.

Authors:  Oksana Maksymchuk; Angela Shysh; Dmytro Stroy
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-26       Impact factor: 6.055
  7 in total

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