Literature DB >> 21455660

A patient undergoing chronic dialysis whose renal anemia was successfully corrected by treatment with cinacalcet.

Yoshiyuki Oshiro1, Hisataka Tanaka, Niro Okimoto.   

Abstract

A 62-year-old female dialysis patient with chronic glomerulonephritis had been receiving hemodialysis therapy for 32 years. In 1985 she underwent a parathyroidectomy for secondary hyperparathyroidism (HPT); however, her parathyroid hormone (PTH) levels gradually increased. Her serum calcium level ranged from 9.0 to 10.0 mg/dL, which caused difficulties in performing vitamin D injection therapy. No parathyroid glands were seen by echography or scintigraphy. On 31 March 2008 her intact PTH (iPTH) level was 895 pg/mL so treatment with cinacalcet 25 mg/day was started. After 3 months her iPTH level decreased to 269 pg/mL and her hemoglobin level increased from 9.3 to 12.9 g/dL. In some cases of severe HPT, anemia improves after parathyroidectomy; however, in this case, cinacalcet improved not only secondary HPT but also anemia.

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Year:  2011        PMID: 21455660     DOI: 10.1007/s10157-011-0433-1

Source DB:  PubMed          Journal:  Clin Exp Nephrol        ISSN: 1342-1751            Impact factor:   2.801


  17 in total

1.  Secondary hyperparathyroidism as cause of resistance to treatment with erythropoietin: effect of parathyroidectomy.

Authors:  M Goicoechea; F Gomez-Campdera; J R Polo; A Tejedor; M A Ruiz; I Vazquez; E Verde; F Valderrabano
Journal:  Clin Nephrol       Date:  1996-06       Impact factor: 0.975

Review 2.  Imaging of the parathyroid in chronic renal failure: diagnostic and therapeutic aspects.

Authors:  M Fukagawa; M Kitaoka; T Inazawa; K Kurokawa
Journal:  Curr Opin Nephrol Hypertens       Date:  1997-07       Impact factor: 2.894

3.  Effect of parathyroidectomy on anemia in chronic renal failure.

Authors:  G L Barbour
Journal:  Arch Intern Med       Date:  1979-08

4.  Parathyroidectomy in chronic renal failure: short- and long-term results on parathyroid function, blood pressure and anemia.

Authors:  G Coen; S Calabria; G Bellinghieri; F Pecchini; F Conte; M G Chiappini; M Ferrannini; C Lagona; A Mallamace; M Manni; M DiLuca; D Sardella; F Taggi
Journal:  Nephron       Date:  2001-06       Impact factor: 2.847

5.  Effects of cinacalcet on bone mineral density in patients with secondary hyperparathyroidism.

Authors:  Yeong-Hau H Lien; Arnold L Silva; David Whittman
Journal:  Nephrol Dial Transplant       Date:  2005-04-19       Impact factor: 5.992

6.  Intravenous calcitriol improves anaemia and reduces the need for erythropoietin in haemodialysis patients.

Authors:  M Goicoechea; M I Vazquez; M A Ruiz; F Gomez-Campdera; R Perez-García; F Valderrábano
Journal:  Nephron       Date:  1998       Impact factor: 2.847

Review 7.  Pharmacological and clinical properties of calcimimetics: calcium receptor activators that afford an innovative approach to controlling hyperparathyroidism.

Authors:  Nobuo Nagano
Journal:  Pharmacol Ther       Date:  2005-08-15       Impact factor: 12.310

8.  Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis.

Authors:  Geoffrey A Block; Kevin J Martin; Angel L M de Francisco; Stewart A Turner; Morrell M Avram; Michael G Suranyi; Gavril Hercz; John Cunningham; Ali K Abu-Alfa; Piergiorgio Messa; Daniel W Coyne; Francesco Locatelli; Raphael M Cohen; Pieter Evenepoel; Sharon M Moe; Albert Fournier; Johann Braun; Laura C McCary; Valter J Zani; Kurt A Olson; Tilman B Drüeke; William G Goodman
Journal:  N Engl J Med       Date:  2004-04-08       Impact factor: 91.245

Review 9.  Erythropoiesis stimulatory agent- resistant anemia in dialysis patients: review of causes and management.

Authors:  Mehmet Kanbay; Mark A Perazella; Benan Kasapoglu; Mustafa Koroglu; Adrian Covic
Journal:  Blood Purif       Date:  2009-10-08       Impact factor: 2.614

10.  Correlation of bone histology with parathyroid hormone, vitamin D3, and radiology in end-stage renal disease.

Authors:  A J Hutchison; R W Whitehouse; H F Boulton; J E Adams; E B Mawer; T J Freemont; R Gokal
Journal:  Kidney Int       Date:  1993-11       Impact factor: 10.612

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