AIM: To evaluate the association between of the interleukin-10 (IL-10) promoter polymorphisms and survival of advanced gastric cancer (GC) patients. METHODS: The IL-10 (-1082, rs1800896; -819, rs1800871; and-592, rs1800896) genotypes in 234 patients with advanced gastric cancer and in 243 healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression for the associations between IL-10 genotypes and the risk of GC. The Kaplan-Meier method with log-rank testing was used to evaluate the association between genotype and survival of the patients. RESULTS: The IL-10 -1082 G allele and GCC (-1082, -819 and -592) haplotype were associated with increased gastric cancer risks (OR 1.2, 95% CI 0.6-3.2, P = 0.007, for -1082 G allele, OR = 2.3, 95% CI, 1.2-4.1, P = 0.005, for GCC haplotype, respectively). However, none of the three IL-10 gene polymorphisms (-1082, -819 and -592) was correlated with gastric cancer survival (P > 0.05), and none of the genotypes of the three IL-10 sites was found as independent prognostic risk factors in the multivariate test. CONCLUSION: IL-10 gene promoter polymorphisms may not be associated with the prognosis of advanced gastric cancer.
AIM: To evaluate the association between of the interleukin-10 (IL-10) promoter polymorphisms and survival of advanced gastric cancer (GC) patients. METHODS: The IL-10 (-1082, rs1800896; -819, rs1800871; and-592, rs1800896) genotypes in 234 patients with advanced gastric cancer and in 243 healthy controls were determined by polymerase chain reaction-restriction fragment length polymorphism assay. Odds ratios (OR) and 95% confidence intervals (CI) were calculated by unconditional logistic regression for the associations between IL-10 genotypes and the risk of GC. The Kaplan-Meier method with log-rank testing was used to evaluate the association between genotype and survival of the patients. RESULTS: The IL-10 -1082 G allele and GCC (-1082, -819 and -592) haplotype were associated with increased gastric cancer risks (OR 1.2, 95% CI 0.6-3.2, P = 0.007, for -1082 G allele, OR = 2.3, 95% CI, 1.2-4.1, P = 0.005, for GCC haplotype, respectively). However, none of the three IL-10 gene polymorphisms (-1082, -819 and -592) was correlated with gastric cancer survival (P > 0.05), and none of the genotypes of the three IL-10 sites was found as independent prognostic risk factors in the multivariate test. CONCLUSION:IL-10 gene promoter polymorphisms may not be associated with the prognosis of advanced gastric cancer.
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Authors: María Asunción García-González; Angel Lanas; Enrique Quintero; David Nicolás; Adolfo Parra-Blanco; Mark Strunk; Rafael Benito; Miguel Angel Simón; Santos Santolaria; Federico Sopeña; Elena Piazuelo; Pilar Jiménez; Cristina Pascual; Eva Mas; Pilar Irún; Jesús Espinel; Rafael Campo; Marisa Manzano; Fernando Geijo; Maria Pellisé; Ferrán González-Huix; Miguel Nieto; Jorge Espinós; Llúcia Titó; Luis Bujanda; Manuel Zaballa Journal: Am J Gastroenterol Date: 2007-07-19 Impact factor: 10.864
Authors: María Asunción García-González; David Nicolás-Pérez; Angel Lanas; Luis Bujanda; Patricia Carrera; Rafael Benito; Mark Strunk; Federico Sopeña; Santos Santolaria; Elena Piazuelo; Pilar Jiménez; Rafael Campo; Jesús Espinel; Marisa Manzano; Fernando Geijo; María Pellisé; Ferrán González-Huix; Jorge Espinós; Manuel Zaballa; Llúcia Titó; Luis Barranco; Roberto Pazo; Enrique Quintero Journal: PLoS One Date: 2012-09-28 Impact factor: 3.240