Literature DB >> 21455216

Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases.

A W Langerak1, F Davi, P Ghia, A Hadzidimitriou, F Murray, K N Potter, R Rosenquist, K Stamatopoulos, C Belessi.   

Abstract

Immunoglobulin gene sequence analysis is widely utilized for prognostication in chronic lymphocytic leukemia (CLL) and the definition of standardized procedures has allowed reliable and reproducible results. Occasionally, a straightforward interpretation of the sequences is not possible because of the so-called 'problematic sequences' that do not fit the 'classic' interpretation and pose scientific questions at the cross-road between hematology and immunology. Thanks to a dedicated effort within the European Research Initiative on CLL (ERIC), we have now the possibility to present such cases, offer a scientific explanation and propose recommendations in terms of prognostication.

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Year:  2011        PMID： 21455216     DOI： 10.1038/leu.2011.49

Source DB:  PubMed          Journal:  Leukemia        ISSN： 0887-6924            Impact factor:   11.528


  23 in total

1.  Multiple productive immunoglobulin heavy chain gene rearrangements in chronic lymphocytic leukemia are mostly derived from independent clones.

Authors:  Karla Plevova; Hana Skuhrova Francova; Katerina Burckova; Yvona Brychtova; Michael Doubek; Sarka Pavlova; Jitka Malcikova; Jiri Mayer; Boris Tichy; Sarka Pospisilova
Journal:  Haematologica       Date:  2013-09-13       Impact factor: 9.941

2.  Immunoglobulin genes in chronic lymphocytic leukemia: key to understanding the disease and improving risk stratification.

Authors:  Lesley-Ann Sutton; Anastasia Hadzidimitriou; Panagiotis Baliakas; Andreas Agathangelidis; Anton W Langerak; Stephan Stilgenbauer; Sarka Pospisilova; Zadie Davis; Francesco Forconi; Frederic Davi; Paolo Ghia; Richard Rosenquist; Kostas Stamatopoulos
Journal:  Haematologica       Date:  2017-06       Impact factor: 9.941

3.  Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.

Authors:  Panagiotis Baliakas; Andreas Agathangelidis; Anastasia Hadzidimitriou; Lesley-Ann Sutton; Eva Minga; Athina Tsanousa; Lydia Scarfò; Zadie Davis; Xiao-Jie Yan; Tait Shanafelt; Karla Plevova; Yorick Sandberg; Fie Juhl Vojdeman; Myriam Boudjogra; Tatiana Tzenou; Maria Chatzouli; Charles C Chu; Silvio Veronese; Anne Gardiner; Larry Mansouri; Karin E Smedby; Lone Bredo Pedersen; Denis Moreno; Kirsten Van Lom; Véronique Giudicelli; Hana Skuhrova Francova; Florence Nguyen-Khac; Panagiotis Panagiotidis; Gunnar Juliusson; Lefteris Angelis; Achilles Anagnostopoulos; Marie-Paule Lefranc; Monica Facco; Livio Trentin; Mark Catherwood; Marco Montillo; Christian H Geisler; Anton W Langerak; Sarka Pospisilova; Nicholas Chiorazzi; David Oscier; Diane F Jelinek; Nikos Darzentas; Chrysoula Belessi; Frederic Davi; Paolo Ghia; Richard Rosenquist; Kostas Stamatopoulos
Journal:  Blood       Date:  2014-12-17       Impact factor: 22.113

4.  Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy.

Authors:  Jennifer A Woyach; Kelly Smucker; Lisa L Smith; Arletta Lozanski; Yiming Zhong; Amy S Ruppert; David Lucas; Katie Williams; Weiqiang Zhao; Laura Rassenti; Emanuela Ghia; Thomas J Kipps; Rose Mantel; Jeffrey Jones; Joseph Flynn; Kami Maddocks; Susan O'Brien; Richard R Furman; Danelle F James; Fong Clow; Gerard Lozanski; Amy J Johnson; John C Byrd
Journal:  Blood       Date:  2014-01-10       Impact factor: 22.113

5.  Targeted deep sequencing reveals clinically relevant subclonal IgHV rearrangements in chronic lymphocytic leukemia.

Authors:  B Stamatopoulos; A Timbs; D Bruce; T Smith; R Clifford; P Robbe; A Burns; D V Vavoulis; L Lopez; P Antoniou; J Mason; H Dreau; A Schuh
Journal:  Leukemia       Date:  2016-10-31       Impact factor: 11.528

6.  Immunoglobulin heavy variable (IGHV) genes and alleles: new entities, new names and implications for research and prognostication in chronic lymphocytic leukaemia.

Authors:  Aliki Xochelli; Andreas Agathangelidis; Ioannis Kavakiotis; Evangelia Minga; Lesley Ann Sutton; Panagiotis Baliakas; Ioanna Chouvarda; Véronique Giudicelli; Ioannis Vlahavas; Nikos Maglaveras; Lisa Bonello; Livio Trentin; Alessandra Tedeschi; Panagiotis Panagiotidis; Christian Geisler; Anton W Langerak; Sarka Pospisilova; Diane F Jelinek; David Oscier; Nicholas Chiorazzi; Nikos Darzentas; Fred Davi; Paolo Ghia; Richard Rosenquist; Anastasia Hadzidimitriou; Chrysoula Belessi; Marie-Paule Lefranc; Kostas Stamatopoulos
Journal:  Immunogenetics       Date:  2014-11-12       Impact factor: 2.846

7.  Dielectrophoretic isolation and detection of cancer-related circulating cell-free DNA biomarkers from blood and plasma.

Authors:  Avery Sonnenberg; Jennifer Y Marciniak; Elaine A Skowronski; Sareh Manouchehri; Laura Rassenti; Emanuela M Ghia; George F Widhopf; Thomas J Kipps; Michael J Heller
Journal:  Electrophoresis       Date:  2014-05-14       Impact factor: 3.535

8.  Basal Ca(2+) signaling is particularly increased in mutated chronic lymphocytic leukemia.

Authors:  A F Muggen; S Y Pillai; L P Kil; M C van Zelm; J J M van Dongen; R W Hendriks; A W Langerak
Journal:  Leukemia       Date:  2014-06-11       Impact factor: 11.528

9.  IMGT-ONTOLOGY 2012.

Authors:  Véronique Giudicelli; Marie-Paule Lefranc
Journal:  Front Genet       Date:  2012-05-23       Impact factor: 4.599

Review 10.  Immune Gene Rearrangements: Unique Signatures for Tracing Physiological Lymphocytes and Leukemic Cells.

Authors:  Michaela Kotrova; Nikos Darzentas; Christiane Pott; Claudia D Baldus; Monika Brüggemann
Journal:  Genes (Basel)       Date:  2021-06-27       Impact factor: 4.096
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