OBJECTIVE: To describe successful long-term tumor control in metastatic adrenocortical carcinoma, a relatively rare tumor with limited treatment options outside of surgery. METHODS: We present the clinical, radiologic, and pathologic findings in a patient with failure of or intolerance to conventional treatments for metastatic adrenocortical carcinoma. RESULTS: A 48-year-old man with adrenocortical carcinoma had disease progression with systemic therapies including mitotane, 5-fluorouracil, streptozotocin, bevacizumab, and external beam radiation therapy. Treatment with all chemotherapeutic drugs was ceased, and he was prescribed mebendazole, 100 mg twice daily, as a single agent. His metastases initially regressed and subsequently remained stable. While receiving mebendazole as a sole treatment for 19 months, his disease remained stable. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory. His disease subsequently progressed after 24 months of mebendazole monotherapy. CONCLUSION: Mebendazole may achieve long-term disease control of metastatic adrenocortical carcinoma. It is well tolerated and the associated adverse effects are minor.
OBJECTIVE: To describe successful long-term tumor control in metastatic adrenocortical carcinoma, a relatively rare tumor with limited treatment options outside of surgery. METHODS: We present the clinical, radiologic, and pathologic findings in a patient with failure of or intolerance to conventional treatments for metastatic adrenocortical carcinoma. RESULTS: A 48-year-old man with adrenocortical carcinoma had disease progression with systemic therapies including mitotane, 5-fluorouracil, streptozotocin, bevacizumab, and external beam radiation therapy. Treatment with all chemotherapeutic drugs was ceased, and he was prescribed mebendazole, 100 mg twice daily, as a single agent. His metastases initially regressed and subsequently remained stable. While receiving mebendazole as a sole treatment for 19 months, his disease remained stable. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory. His disease subsequently progressed after 24 months of mebendazole monotherapy. CONCLUSION:Mebendazole may achieve long-term disease control of metastatic adrenocortical carcinoma. It is well tolerated and the associated adverse effects are minor.
Authors: Andrew R Larsen; Ren-Yuan Bai; Jon H Chung; Alexandra Borodovsky; Charles M Rudin; Gregory J Riggins; Fred Bunz Journal: Mol Cancer Ther Date: 2014-11-05 Impact factor: 6.261
Authors: Martin Michaelis; Bishr Agha; Florian Rothweiler; Nadine Löschmann; Yvonne Voges; Michel Mittelbronn; Tatjana Starzetz; Patrick N Harter; Behnaz A Abhari; Simone Fulda; Frank Westermann; Kristoffer Riecken; Silvia Spek; Klaus Langer; Michael Wiese; Wilhelm G Dirks; Richard Zehner; Jaroslav Cinatl; Mark N Wass; Jindrich Cinatl Journal: Sci Rep Date: 2015-02-03 Impact factor: 4.379
Authors: Cynthia M Simbulan-Rosenthal; Sivanesan Dakshanamurthy; Anirudh Gaur; You-Shin Chen; Hong-Bin Fang; Maryam Abdussamad; Hengbo Zhou; John Zapas; Valerie Calvert; Emanuel F Petricoin; Michael B Atkins; Stephen W Byers; Dean S Rosenthal Journal: Oncotarget Date: 2017-02-21