Literature DB >> 21453275

Gene expression significance in personalized medicine of non-small-cell lung cancer and gene expression analyzing platforms.

Li Zhang1, Huiyi Yang, Jiasen Xu.   

Abstract

The association between gene expression and clinical characteristics of non-small cell lung cancer (NSCLC) are uncovered. These genes are critical elements in carcinoma physiological processes, including DNA synthesis, DNA repair and mitosis. Genes such as ERCC1, RRM1, TYMS, TUBB3 and STMN1 are predictive biomarker candidates for chemotherapy sensitivity in patients with NSCLC. Suitable gene expression analyzing technology is key factor for the personalize medicine to become a reality. This mini-review will describe and discuss critically on most currently widely used gene expression analyzing technologies, involving immunohistochemistry (IHC), reverse-transcription quantitative PCR (RT-qPCR) and branch-DNA technology (bDNA).

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Year:  2011        PMID： 21453275     DOI： 10.2174/138920011795495303

Source DB:  PubMed          Journal:  Curr Drug Metab        ISSN： 1389-2002            Impact factor:   3.731


  5 in total

Review 1.  Evaluation of molecular prognostic and predictive factors: an important step towards personalised treatment in non small cell lung cancer.

Authors:  Alfredo Tartarone; Rose Lerose; Giuseppina Gallucci; Raffaele Ardito; Michele Aieta
Journal:  Med Oncol       Date:  2011-06-02       Impact factor: 3.064

Review 2.  Far upstream element binding protein 1: a commander of transcription, translation and beyond.

Authors:  J Zhang; Q M Chen
Journal:  Oncogene       Date:  2012-08-27       Impact factor: 9.867

3.  Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.

Authors:  Melissa Paoloni; Craig Webb; Christina Mazcko; David Cherba; William Hendricks; Susan Lana; E J Ehrhart; Brad Charles; Heather Fehling; Leena Kumar; David Vail; Michael Henson; Michael Childress; Barbara Kitchell; Christopher Kingsley; Seungchan Kim; Mark Neff; Barbara Davis; Chand Khanna; Jeffrey Trent
Journal:  PLoS One       Date:  2014-03-17       Impact factor: 3.240

4.  Promyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migration.

Authors:  Mei Kuen Tang; Yong Jia Liang; John Yeuk Hon Chan; Sing Wan Wong; Elve Chen; Yao Yao; Jingyi Gan; Lihai Xiao; Hin Cheung Leung; Hsiang Fu Kung; Hua Wang; Kenneth Ka Ho Lee
Journal:  PLoS One       Date:  2013-03-21       Impact factor: 3.240

5.  Clinical application of drug sensitive gene detection in postoperative instillation for non-muscle invasive bladder cancer.

Authors:  Zhenlong Wang; Hui Tang; Yuquan Xue; Li Xue; Hongliang Li; Tie Chong
Journal:  BMC Nephrol       Date:  2020-10-07       Impact factor: 2.388
  5 in total

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