Literature DB >> 21453258

Nanocrystal technology in the delivery of poorly soluble drugs: an overview.

Ramesh C Nagarwal1, Rakesh Kumar, Meenakshi Dhanawat, Nirupam Das, J K Pandit.   

Abstract

Extensive attempts to overcome problems related to solubility of drugs for maximizing bioavailability at targeted sites in the body have been made. The issue of drug solubility appears to attract the continued interest of pharmaceutical manufacturers. In this context, nanocrystallization has emerged as an important tool. In the present review, the authors discuss the advantages of nanocrystallized drugs and examine the products available in the market as well as drugs in the pipeline using nanocrystal-based formulations, which are being developed by pharmaceutical companies for drug delivery.

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Year:  2011        PMID： 21453258     DOI： 10.2174/156720111795767988

Source DB:  PubMed          Journal:  Curr Drug Deliv        ISSN： 1567-2018            Impact factor:   2.565


  10 in total

Review 1.  Nanocrystals for Improving Oral Bioavailability of Drugs: Intestinal Transport Mechanisms and Influencing Factors.

Authors:  Zonghua Tian; Yaping Mai; Tingting Meng; Shijie Ma; Guojing Gou; Jianhong Yang
Journal:  AAPS PharmSciTech       Date:  2021-06-14       Impact factor: 3.246

Review 2.  Microemulsion systems: from the design and architecture to the building of a new delivery system for multiple-route drug delivery.

Authors:  E S T Egito; L Amaral-Machado; E N Alencar; A G Oliveira
Journal:  Drug Deliv Transl Res       Date:  2020-11-08       Impact factor: 4.617

3.  Improved bioavailability of a water-insoluble drug by inhalation of drug-containing maltosyl-β-cyclodextrin microspheres using a four-fluid nozzle spray drier.

Authors:  Tetsuya Ozeki; Yoshihito Kano; Norimitsu Takahashi; Tatsuaki Tagami; Hiroaki Okada
Journal:  AAPS PharmSciTech       Date:  2012-09-01       Impact factor: 3.246

Review 4.  Nanotechnology applications in thoracic surgery.

Authors:  Sophie C Hofferberth; Mark W Grinstaff; Yolonda L Colson
Journal:  Eur J Cardiothorac Surg       Date:  2016-02-02       Impact factor: 4.191

5.  Nanocrystals of a new camptothecin derivative WCN-21 enhance its solubility and efficacy.

Authors:  Jia You; Yuyuan Chen; Zubaeda M Mohamed Alsayeh; Xingyu Shen; Chun Li; Pengxuan Zhao; Fei Chen; Yingqian Liu; Chuanrui Xu
Journal:  Oncotarget       Date:  2017-05-02

6.  Dual-functional Brij-S20-modified nanocrystal formulation enhances the intestinal transport and oral bioavailability of berberine.

Authors:  Wei Xiong; Wei Sang; Ke Gang Linghu; Zhang Feng Zhong; Wai San Cheang; Juan Li; Yuan Jia Hu; Hua Yu; Yi Tao Wang
Journal:  Int J Nanomedicine       Date:  2018-06-28

Review 7.  Microneedle-Mediated Transdermal Delivery of Drug-Carrying Nanoparticles.

Authors:  Xue Jiang; Huanhuan Zhao; Wei Li
Journal:  Front Bioeng Biotechnol       Date:  2022-02-11

Review 8.  Synthesis of Prussian Blue Nanoparticles and Their Antibacterial, Antiinflammation and Antitumor Applications.

Authors:  Danyang Li; Meng Liu; Wenyao Li; Qiang Fu; Liyang Wang; Enping Lai; Weixin Zhao; Kaile Zhang
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-21

Review 9.  Injected nanocrystals for targeted drug delivery.

Authors:  Yi Lu; Ye Li; Wei Wu
Journal:  Acta Pharm Sin B       Date:  2016-01-11       Impact factor: 11.413

10.  Preparation of oridonin nanocrystals and study of their endocytosis and transcytosis behaviours on MDCK polarized epithelial cells.

Authors:  Huagang Sheng; Yuanyuan Zhang; Jijuan Nai; Shaohua Wang; Mengmeng Dai; Guitao Lin; Liqiao Zhu; Qiang Zhang
Journal:  Pharm Biol       Date:  2020-12       Impact factor: 3.889
  10 in total

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