Literature DB >> 21451868

First efficient uncharged reactivators for the dephosphylation of poisoned human acetylcholinesterase.

Guillaume Mercey1, Tristan Verdelet, Géraldine Saint-André, Emilie Gillon, Alain Wagner, Rachid Baati, Ludovic Jean, Florian Nachon, Pierre-Yves Renard.   

Abstract

Nerve agents are highly toxic organophosphorus compounds with strong inhibition potency against acetylcholinesterase (AChE). Herein, we describe two first extremely promising uncharged reactivators for poisoned human AChE with a superior or similar in vitro ability to reactivate the enzyme as compared to that of HI-6, obidoxime, TMB-4 and HLö-7. © The Royal Society of Chemistry 2011

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21451868     DOI： 10.1039/c1cc10787a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  17 in total

1.  Mechanism of interaction of novel uncharged, centrally active reactivators with OP-hAChE conjugates.

Authors:  Zoran Radić; Rakesh K Sit; Edzna Garcia; Limin Zhang; Suzana Berend; Zrinka Kovarik; Gabriel Amitai; Valery V Fokin; K Barry Sharpless; Palmer Taylor
Journal:  Chem Biol Interact       Date:  2012-09-04       Impact factor: 5.192

2.  Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.

Authors:  Rakesh K Sit; Zrinka Kovarik; Nikolina Maček Hrvat; Suzana Žunec; Carol Green; Valery V Fokin; K Barry Sharpless; Zoran Radić; Palmer Taylor
Journal:  J Pharmacol Exp Ther       Date:  2018-09-06       Impact factor: 4.030

3.  Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases.

Authors:  Zoran Radić; Rakesh K Sit; Zrinka Kovarik; Suzana Berend; Edzna Garcia; Limin Zhang; Gabriel Amitai; Carol Green; Bozica Radić; Valery V Fokin; K Barry Sharpless; Palmer Taylor
Journal:  J Biol Chem       Date:  2012-02-16       Impact factor: 5.157

4.  Kinetic assessment of N-methyl-2-methoxypyridinium species as phosphonate anion methylating agents.

Authors:  Joseph J Topczewski; Daniel M Quinn
Journal:  Org Lett       Date:  2013-02-14       Impact factor: 6.005

5.  A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning.

Authors:  Ophélie Da Silva; Nicolas Probst; Christophe Landry; Anne-Sophie Hanak; Pierre Warnault; Caroline Coisne; André-Guilhem Calas; Fabien Gosselet; Charlotte Courageux; Anne-Julie Gastellier; Marilène Trancart; Rachid Baati; Marie-Pierre Dehouck; Ludovic Jean; Florian Nachon; Pierre-Yves Renard; José Dias
Journal:  J Med Chem       Date:  2022-03-07       Impact factor: 7.446

6.  Centrally acting oximes in reactivation of tabun-phosphoramidated AChE.

Authors:  Zrinka Kovarik; Nikolina Maček; Rakesh K Sit; Zoran Radić; Valery V Fokin; K Barry Sharpless; Palmer Taylor
Journal:  Chem Biol Interact       Date:  2012-09-07       Impact factor: 5.192

Review 7.  Oxime-mediated reactivation of organophosphate-inhibited acetylcholinesterase with emphasis on centrally-active oximes.

Authors:  Janice E Chambers; Mary B Dail; Edward C Meek
Journal:  Neuropharmacology       Date:  2020-06-13       Impact factor: 5.250

8.  Evaluation of high-affinity phenyltetrahydroisoquinoline aldoximes, linked through anti-triazoles, as reactivators of phosphylated cholinesterases.

Authors:  Nikolina Maček Hrvat; Jarosław Kalisiak; Goran Šinko; Zoran Radić; K Barry Sharpless; Palmer Taylor; Zrinka Kovarik
Journal:  Toxicol Lett       Date:  2019-12-19       Impact factor: 4.372

Review 9.  Central neuroprotection demonstrated by novel oxime countermeasures to nerve agent surrogates.

Authors:  Janice E Chambers; Edward C Meek
Journal:  Ann N Y Acad Sci       Date:  2020-04-21       Impact factor: 6.499

10.  In silico studies in probing the role of kinetic and structural effects of different drugs for the reactivation of tabun-inhibited AChE.

Authors:  Rabindranath Lo; Nellore Bhanu Chandar; Manoj K Kesharwani; Aastha Jain; Bishwajit Ganguly
Journal:  PLoS One       Date:  2013-12-02       Impact factor: 3.240
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.