Literature DB >> 21451734

Pentamidine Congeners 1: Synthesis of Cis- and Trans-Butamidine Analogues As Anti-Pneumocystis carinii Pneumonia Agents.

Isaac O Donkor1, Susan K Jones, Richard R Tidwell.   

Abstract

Butamidine analogues possessing unsaturation in the ether bridge between the bisamidinophenyl or bisimidazolinophenyl functionalities have been synthesized as semirigid congeners of pentamidine. These compounds demonstrated good anti-P. carinii pueumonia activity in a rat model of the disease.

Entities:  

Year:  1993        PMID： 21451734      PMCID： PMC3065065          DOI： 10.1016/S0960-894X(00)80302-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  11 in total

1.  Analogues of 1,5-bis(4-amidinophenoxy)pentane (pentamidine) in the treatment of experimental Pneumocystis carinii pneumonia.

Authors:  R R Tidwell; S K Jones; J D Geratz; K A Ohemeng; M Cory; J E Hall
Journal:  J Med Chem       Date:  1990-04       Impact factor: 7.446

2.  Diamidino-alpha,omega-diphenoxyalkanes. Structure-activity relationships for the inhibition of thrombin, pancreatic kallikrein, and trypsin.

Authors:  J D Geratz; A C Whitmore
Journal:  J Med Chem       Date:  1973-09       Impact factor: 7.446

3.  The effects of antimicrobial agents on ribonucleic acid polymerase.

Authors:  M J Waring
Journal:  Mol Pharmacol       Date:  1965-07       Impact factor: 4.436

4.  Latent Pneumocystis infection of rats, relapse, and chemotherapy.

Authors:  J K Frenkel; J T Good; J A Shultz
Journal:  Lab Invest       Date:  1966-10       Impact factor: 5.662

5.  Update: acquired immunodeficiency syndrome--United States.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  1985-05-10       Impact factor: 17.586

6.  Pharmacologic aspects of pentamidine.

Authors:  T P Waalkes; D R Makulu
Journal:  Natl Cancer Inst Monogr       Date:  1976-10

7.  Polyamine metabolism in Pneumocystis carinii.

Authors:  G Y Lipschik; H Masur; J A Kovacs
Journal:  J Infect Dis       Date:  1991-05       Impact factor: 5.226

8.  New aromatic diamidines with central alpha-oxyalkane or alpha, omega-dioxyalkane chains. Structure-activity relationships for the inhibition of trypsin, pancreatic kallikrein, and thrombin and for the inhibition of the overall coagulation process.

Authors:  J D Geratz; M C Cheng; R R Tidwell
Journal:  J Med Chem       Date:  1975-05       Impact factor: 7.446

9.  Cationic antitrypanosomal and other antimicrobial agents in the therapy of experimental Pneumocystis carinii pneumonia.

Authors:  P D Walzer; C K Kim; J Foy; M J Linke; M T Cushion
Journal:  Antimicrob Agents Chemother       Date:  1988-06       Impact factor: 5.191

10.  Assessment of therapy for pneumocystis carinii pneumonia. PCP Therapy Project Group.

Authors:  H W Haverkos
Journal:  Am J Med       Date:  1984-03       Impact factor: 4.965
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