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Literature DB >> 21451511

Clonal interrogation of stem cells.

Abstract

Individual stem cells are functionally defined by their self-renewal and differentiation potential. Methods for clonal analysis are essential for understanding stem cells, particularly given the increasing evidence for stem-cell heterogeneity. Stem cells reside within complex microenvironments, making single-cell analysis particularly challenging. Furthermore, simultaneous molecular and functional characterization of single stem cells is not trivial. Here we explore clonal assays applied to stem cell biology and their use in understanding the cellular and molecular basis of stem-cell identity.

Mesh：

Year: 2011 PMID： 21451511 DOI： 10.1038/nmeth.1590

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

54 in total

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6. Differences in the frequency of normal and clonal precursors of colony-forming cells in chronic myelogenous leukemia and acute myelogenous leukemia.

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7. Hematopoietic stem cells engraft in mice with absolute efficiency.

Authors: Patricia Benveniste; Claude Cantin; Deborah Hyam; Norman N Iscove
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8. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.

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9. Identification of stem cells in small intestine and colon by marker gene Lgr5.

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Review 10. Development and applications of single-cell transcriptome analysis.

Authors: Fuchou Tang; Kaiqin Lao; M Azim Surani
Journal: Nat Methods Date: 2011-04 Impact factor: 28.547

17 in total

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8. Three-color femtosecond source for simultaneous excitation of three fluorescent proteins in two-photon fluorescence microscopy.

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9. Heterogeneous structure of stem cells dynamics: statistical models and quantitative predictions.

Authors: Paul Bogdan; Bridget M Deasy; Burhan Gharaibeh; Timo Roehrs; Radu Marculescu
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10. iTRAQ-based proteomic analysis of polyploid giant cancer cells and budding progeny cells reveals several distinct pathways for ovarian cancer development.

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