OBJECTIVE: The oxygen uptake efficiency slope (OUES) has been proposed as an independent and objective alternative to the peak oxygen uptake (VO(2peak)), which does not require maximal exercise. The aim of this study was to investigate the construct and group validity of the OUES in children with congenital heart disease (CHD). METHODS: Thirty-one patients with CHD, of which 16 patients (mean age ± SD 11.2 ± 2.7 years) with a Fontan repair and 15 patients (mean age ± SD 13.2 ± 3.6 years) with surgical repair of tetralogy of Fallot (ToF) completed a symptom-limited cardiopulmonary exercise test. The OUES was calculated and normalized for body surface area at three different exercise intensities: (1) using 100% of the exercise data; (2) using the first 75% of the exercise data; and (3) using exercise data up to the ventilatory threshold (VT). Furthermore, peak oxygen uptake (VO(2peak)), VT, ventilatory efficiency (V(E)/VO(2)-slope), and ventilatory drive (V(E)/VCO(2)-slope) were calculated and compared with values of 46 healthy children (mean age ± SD 12.2 ± 2.4 years). RESULTS: In all three groups, the OUES values determined at the three different exercise intensities were not significantly different from each other. Moreover, the OUES was significantly reduced in the children with CHD, with significantly lower values in the Fontan patients compared to ToF. Strong correlations were found between the OUES and both the VO(2peak) and VT in Fontan and ToF patients. DISCUSSION: The OUES provides a valid measure of cardiopulmonary fitness in children with CHD, which is independent of exercise intensity and strongly correlated with VO(2peak) and VT (construct validity). Furthermore, the OUES is capable of differentiating between healthy children and children with CHD and between Fontan and ToF patients (group validity). Therefore, the OUES may be a valid, effort-independent parameter of cardiopulmonary fitness in children with CHD.
OBJECTIVE: The oxygen uptake efficiency slope (OUES) has been proposed as an independent and objective alternative to the peak oxygen uptake (VO(2peak)), which does not require maximal exercise. The aim of this study was to investigate the construct and group validity of the OUES in children with congenital heart disease (CHD). METHODS: Thirty-one patients with CHD, of which 16 patients (mean age ± SD 11.2 ± 2.7 years) with a Fontan repair and 15 patients (mean age ± SD 13.2 ± 3.6 years) with surgical repair of tetralogy of Fallot (ToF) completed a symptom-limited cardiopulmonary exercise test. The OUES was calculated and normalized for body surface area at three different exercise intensities: (1) using 100% of the exercise data; (2) using the first 75% of the exercise data; and (3) using exercise data up to the ventilatory threshold (VT). Furthermore, peak oxygen uptake (VO(2peak)), VT, ventilatory efficiency (V(E)/VO(2)-slope), and ventilatory drive (V(E)/VCO(2)-slope) were calculated and compared with values of 46 healthy children (mean age ± SD 12.2 ± 2.4 years). RESULTS: In all three groups, the OUES values determined at the three different exercise intensities were not significantly different from each other. Moreover, the OUES was significantly reduced in the children with CHD, with significantly lower values in the Fontan patients compared to ToF. Strong correlations were found between the OUES and both the VO(2peak) and VT in Fontan and ToF patients. DISCUSSION: The OUES provides a valid measure of cardiopulmonary fitness in children with CHD, which is independent of exercise intensity and strongly correlated with VO(2peak) and VT (construct validity). Furthermore, the OUES is capable of differentiating between healthy children and children with CHD and between Fontan and ToF patients (group validity). Therefore, the OUES may be a valid, effort-independent parameter of cardiopulmonary fitness in children with CHD.
Authors: Covadonga Terol Espinosa de Los Monteros; Roel L F Van der Palen; Mark G Hazekamp; Lukas Rammeloo; Monique R M Jongbloed; Nico A Blom; Arend D J Ten Harkel Journal: Pediatr Cardiol Date: 2021-02-01 Impact factor: 1.655
Authors: Vojtěch Illinger; Ondřej Materna; Kryštof Slabý; Denisa Jičínská; Jan Kovanda; Karel Koubský; Jan Pokorný; Michal Procházka; Petra Antonová; Antonín Hoskovec; Jiří Radvanský; Václav Chaloupecký; Jan Janoušek Journal: ESC Heart Fail Date: 2021-12-10
Authors: A Christian Blank; Sara Hakim; Jan L Strengers; Ronald B Tanke; Toon A van Veen; Marc A Vos; Tim Takken Journal: Pediatr Cardiol Date: 2012-02-14 Impact factor: 1.655
Authors: Camilla Astley; Maria Fernanda Badue Pereira; Marcos Santos Lima; Carlos Alberto Buchpiguel; Camila G Carneiro; Marcelo Tatit Sapienza; Gabriela Nunes Leal; Danilo Marcelo Leite do Prado; Tiago Peçanha; Sofia Mendes Sieczkowska; Olivia Mari Matsuo; Livia Lindoso; Heloisa Helena Marques; Clovis Artur Silva; Bruno Gualano Journal: Physiol Rep Date: 2022-03