BACKGROUND: Several formulas are available to estimate glomerular filtration rate (GFR) at the bedside. A decrease in GFR has been associated with poorer performance. We hypothesized that it is related to worsening disability as well. The aim of this study was to evaluate whether the Modification of Diet in Renal Disease formulas can predict worsening disability better than the classic Cockcroft-Gault formula or the measured creatinine clearance. METHODS: We studied 666 participants in the InCHIANTI study with 6 years of follow-up data. We evaluated whether directly measured creatinine clearance and GFR estimated using the Modification of Diet in Renal Disease and Cockcroft-Gault formulas predict new disability defined as the loss of ≥ 1 ADL over the 6-year follow-up. RESULTS: The mean age was 73.1 years (SD: 6.1), 57.7% were women. Fewer than 5% of participants were disabled at baseline. Eighty-one (12.2%) participants experienced a decline in activities of daily life score at follow-up. Declining GFR was associated with increasing risk of worsening disability (Mantel-Haenszel P < .001), with an increased steepness in the curve at GFR below 60 mL/min. The relative risks for worsening disability in people with GFR less than 60 mL/min/m were 3.19 (95% CI: 2.12-4.79) and 4.40 (95% CI: 2.80-6.94) using the Modification of Diet in Renal Disease and the Cockcroft-Gault equations, respectively. The corresponding figures obtained with measured creatinine clearance was 3.95 (95% CI: 2.60-6.01). After adjustment for potential confounders, however, these estimates were substantially reduced. CONCLUSION: Estimation of renal function with the Cockcroft-Gault or Modification of Diet in Renal Disease formulas can help to identify elderly at risk of worsening disability. The mechanism by which reduced kidney function predicts disability should be further investigated.
BACKGROUND: Several formulas are available to estimate glomerular filtration rate (GFR) at the bedside. A decrease in GFR has been associated with poorer performance. We hypothesized that it is related to worsening disability as well. The aim of this study was to evaluate whether the Modification of Diet in Renal Disease formulas can predict worsening disability better than the classic Cockcroft-Gault formula or the measured creatinine clearance. METHODS: We studied 666 participants in the InCHIANTI study with 6 years of follow-up data. We evaluated whether directly measured creatinine clearance and GFR estimated using the Modification of Diet in Renal Disease and Cockcroft-Gault formulas predict new disability defined as the loss of ≥ 1 ADL over the 6-year follow-up. RESULTS: The mean age was 73.1 years (SD: 6.1), 57.7% were women. Fewer than 5% of participants were disabled at baseline. Eighty-one (12.2%) participants experienced a decline in activities of daily life score at follow-up. Declining GFR was associated with increasing risk of worsening disability (Mantel-Haenszel P < .001), with an increased steepness in the curve at GFR below 60 mL/min. The relative risks for worsening disability in people with GFR less than 60 mL/min/m were 3.19 (95% CI: 2.12-4.79) and 4.40 (95% CI: 2.80-6.94) using the Modification of Diet in Renal Disease and the Cockcroft-Gault equations, respectively. The corresponding figures obtained with measured creatinine clearance was 3.95 (95% CI: 2.60-6.01). After adjustment for potential confounders, however, these estimates were substantially reduced. CONCLUSION: Estimation of renal function with the Cockcroft-Gault or Modification of Diet in Renal Disease formulas can help to identify elderly at risk of worsening disability. The mechanism by which reduced kidney function predicts disability should be further investigated.
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Authors: Andrea Corsonello; Lisanne Tap; Regina Roller-Wirnsberger; Gerhard Wirnsberger; Carmine Zoccali; Tomasz Kostka; Agnieszka Guligowska; Francesco Mattace-Raso; Pedro Gil; Lara Guardado Fuentes; Itshak Meltzer; Ilan Yehoshua; Francesc Formiga-Perez; Rafael Moreno-González; Christian Weingart; Ellen Freiberger; Johan Ärnlöv; Axel C Carlsson; Silvia Bustacchini; Fabrizia Lattanzio Journal: BMC Nephrol Date: 2018-10-11 Impact factor: 2.388
Authors: Rada Artzi-Medvedik; Robert Kob; Paolo Fabbietti; Fabrizia Lattanzio; Andrea Corsonello; Yehudit Melzer; Regina Roller-Wirnsberger; Gerhard Wirnsberger; Francesco Mattace-Raso; Lisanne Tap; Pedro Gil; Sara Lainez Martinez; Francesc Formiga; Rafael Moreno-González; Tomasz Kostka; Agnieszka Guligowska; Johan Ärnlöv; Axel C Carlsson; Ellen Freiberger; Itshak Melzer Journal: BMC Geriatr Date: 2020-10-02 Impact factor: 3.921