PURPOSE: To develop and compare an automated detection system for ischemic lesions in a neonatal model of bilateral carotid artery occlusion with hypoxia (BCAO-H) from T2 weighted MRI (T2WI) to the currently used "gold standard" of manual segmentation. MATERIALS AND METHODS: Forty-three P10 BCAO-H rat pups and 8 controls underwent T2WI at 1 day and 28 days. A computational imaging method, Hierarchical Region Splitting (HRS), was developed to automatically and rapidly detect and quantify 3D lesion and normal appearing brain matter (NABM) volumes. RESULTS: HRS quantified lesion and NABM volumes within 15 s in comparison to 3 h for its manual counterpart, with a high correlation for injury (r(2) = 0. 95; P = 8.6 × 10(-7) ) and NABM (r(2) = 0. 92; P = 1.4 × 10(-22) ). Average lesion volumes for mild, moderate, and severe injuries were 3.85%, 28.85%, and 52.98% for HRS and 0.51%, 24.22%, and 48.74% for manual detection. Lesion volumes and locations were similar for both methods (sensitivity: 0.82, specificity: 0.86, and similarity: 1.47). CONCLUSION: HRS is an accurate, objective, and rapid method to quantify injury evolution in neonatal hypoxic ischemic injury models.
PURPOSE: To develop and compare an automated detection system for ischemic lesions in a neonatal model of bilateral carotid artery occlusion with hypoxia (BCAO-H) from T2 weighted MRI (T2WI) to the currently used "gold standard" of manual segmentation. MATERIALS AND METHODS: Forty-three P10 BCAO-H rat pups and 8 controls underwent T2WI at 1 day and 28 days. A computational imaging method, Hierarchical Region Splitting (HRS), was developed to automatically and rapidly detect and quantify 3D lesion and normal appearing brain matter (NABM) volumes. RESULTS:HRS quantified lesion and NABM volumes within 15 s in comparison to 3 h for its manual counterpart, with a high correlation for injury (r(2) = 0. 95; P = 8.6 × 10(-7) ) and NABM (r(2) = 0. 92; P = 1.4 × 10(-22) ). Average lesion volumes for mild, moderate, and severe injuries were 3.85%, 28.85%, and 52.98% for HRS and 0.51%, 24.22%, and 48.74% for manual detection. Lesion volumes and locations were similar for both methods (sensitivity: 0.82, specificity: 0.86, and similarity: 1.47). CONCLUSION:HRS is an accurate, objective, and rapid method to quantify injury evolution in neonatal hypoxic ischemic injury models.
Authors: Inge A Mulder; Artem Khmelinskii; Oleh Dzyubachyk; Sebastiaan de Jong; Nathalie Rieff; Marieke J H Wermer; Mathias Hoehn; Boudewijn P F Lelieveldt; Arn M J M van den Maagdenberg Journal: Front Neuroinform Date: 2017-01-31 Impact factor: 4.081
Authors: Amandine Jullienne; Mary Hamer; Elizabeth Haddad; Alexander Morita; Peter Gifford; Richard Hartman; William J Pearce; Jiping Tang; John H Zhang; Andre Obenaus Journal: J Neurosci Res Date: 2019-03-20 Impact factor: 4.164
Authors: Mohammad Hjouj; David Last; David Guez; Dianne Daniels; Shirley Sharabi; Jacob Lavee; Boris Rubinsky; Yael Mardor Journal: PLoS One Date: 2012-08-10 Impact factor: 3.240
Authors: Stephen Ashwal; Nirmalya Ghosh; Christine I Turenius; Melissa Dulcich; Christopher M Denham; Beatriz Tone; Richard Hartman; Evan Y Snyder; Andre Obenaus Journal: Pediatr Res Date: 2014-01-24 Impact factor: 3.756