Literature DB >> 21448653

Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria.

Areli Gutiérrez-Pérez1, Christian Cortés-Rojo, Ruth Noriega-Cisneros, Elizabeth Calderón-Cortés, Salvador Manzo-Avalos, Mónica Clemente-Guerrero, Daniel Godínez-Hernández, Istvan Boldogh, Alfredo Saavedra-Molina.   

Abstract

Trans-resveratrol is a nutraceutical with known antioxidant, anti-inflammatory, cardioprotective, and anti-apoptotic properties. The aim of this study was to evaluate the effects of resveratrol on heart mitochondria. Resveratrol significantly decreased Fe(2+) + ascorbate oxidant system-induced lipid peroxide levels, preserved physiological levels of glutathione, and increased nitric oxide (NO) levels in mitochondria. Under calcium-mediated stress, there was a 2.7-fold increase in the NO levels, and a mild decoupling in the mitochondrial respiratory chain. These results provide a mechanism for and support the beneficial effects of resveratrol under pathological conditions induced by oxidative stress and calcium overload. In addition, these findings underscore the usefulness of resveratrol in the prevention of cardiovascular diseases.

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Year:  2011        PMID： 21448653     DOI： 10.1007/s10863-011-9349-4

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   2.945


  42 in total

Review 1.  Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells.

Authors:  Elinor J Griffiths; Guy A Rutter
Journal:  Biochim Biophys Acta       Date:  2009-02-03

2.  Antioxidative activity of resveratrol and its derivatives isolated from seeds of Paeonia lactiflora.

Authors:  Hyo Jin Kim; Eun Ju Chang; Sung Hee Cho; Shin Kyo Chung; Heui Dong Park; Sang Won Choi
Journal:  Biosci Biotechnol Biochem       Date:  2002-09       Impact factor: 2.043

3.  Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia.

Authors:  Vilmante Borutaite; Aiste Jekabsone; Ramune Morkuniene; Guy C Brown
Journal:  J Mol Cell Cardiol       Date:  2003-04       Impact factor: 5.000

Review 4.  Mitochondrial calcium transport: physiological and pathological relevance.

Authors:  T E Gunter; K K Gunter; S S Sheu; C E Gavin
Journal:  Am J Physiol       Date:  1994-08

5.  The protective effect of resveratrols on ischaemia-reperfusion injuries of rat hearts is correlated with antioxidant efficacy.

Authors:  Li-Man Hung; Ming-Jai Su; Wing-Keung Chu; Chin-Wei Chiao; Wan-Fen Chan; Jan-Kan Chen
Journal:  Br J Pharmacol       Date:  2002-04       Impact factor: 8.739

6.  Nitric oxide synthase activity in mitochondria.

Authors:  P Ghafourifar; C Richter
Journal:  FEBS Lett       Date:  1997-12-01       Impact factor: 4.124

Review 7.  Uncouplers of oxidative phosphorylation.

Authors:  H Terada
Journal:  Environ Health Perspect       Date:  1990-07       Impact factor: 9.031

8.  Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin.

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Journal:  Circ Res       Date:  2003-12-01       Impact factor: 17.367

9.  Elucidation of the effects of lipoperoxidation on the mitochondrial electron transport chain using yeast mitochondria with manipulated fatty acid content.

Authors:  Christian Cortés-Rojo; Elizabeth Calderón-Cortés; Mónica Clemente-Guerrero; Mirella Estrada-Villagómez; Salvador Manzo-Avalos; Ricardo Mejía-Zepeda; Istvan Boldogh; Alfredo Saavedra-Molina
Journal:  J Bioenerg Biomembr       Date:  2009-02-18       Impact factor: 2.945

10.  Roles of drinking pattern and type of alcohol consumed in coronary heart disease in men.

Authors:  Kenneth J Mukamal; Katherine M Conigrave; Murray A Mittleman; Carlos A Camargo; Meir J Stampfer; Walter C Willett; Eric B Rimm
Journal:  N Engl J Med       Date:  2003-01-09       Impact factor: 91.245
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  2 in total

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Authors:  Michael Maes; Zdenĕk Fišar; Miguel Medina; Giovanni Scapagnini; Gabriel Nowak; Michael Berk
Journal:  Inflammopharmacology       Date:  2012-01-24       Impact factor: 4.473

2.  Resveratrol potentiates effects of simvastatin on inhibition of rat ovarian theca-interstitial cells steroidogenesis.

Authors:  Israel Ortega; Jesus A Villanueva; Donna H Wong; Amanda B Cress; Anna Sokalska; Scott D Stanley; Antoni J Duleba
Journal:  J Ovarian Res       Date:  2014-02-13       Impact factor: 4.234
  2 in total

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