Literature DB >> 2144824

Cardiovascular effects of 5-HT1A receptor agonists injected into the dorsal raphe nucleus of conscious rats.

H E Connor1, G A Higgins.   

Abstract

The aim of this study was to investigate the cardiovascular effects of the 5-HT1A receptor agonists, 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin), flesinoxan and 5-carboxamidotryptamine (5-CT) following injection into the dorsal raphe nucleus of conscious rats. 8-OH-DPAT (0.5-2.5 micrograms), hypotension, bradycardia and flat body posture. In contrast, injection of 8-OH-DPAT (0.5 microgram) into the median raphe nucleus caused no cardiovascular changes or flat body posture. (-)Pindolol (0.5 microgram dorsal raphe nucleus) had little effect on cardiovascular parameters, but significantly attenuated the cardiovascular effects of 8-OH-DPAT (0.5 microgram dorsal raphe nucleus). N-Methylatropine (1 mg/kg i.v.) antagonised the cardiovascular effects of 8-OH-DPAT (0.5 microgram dorsal raphe nucleus), suggesting these were vagally mediated. Both pretreatments also appeared to reduce 8-OH-DPAT-induced flat body posture. The results suggest that 8-OH-DPAT activates 5-HT1A receptors in the dorsal raphe nucleus to cause hypotension and bradycardia.

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Year:  1990        PMID： 2144824     DOI： 10.1016/0014-2999(90)90493-p

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Effect of 5-HT1A receptor agonists in two models of anxiety after dorsal raphe injection.

Authors:  G A Higgins; B J Jones; N R Oakley
Journal:  Psychopharmacology (Berl)       Date:  1992       Impact factor: 4.530

2.  Environment Influencing Serotonin Syndrome Induced by Ecstasy Abuse.

Authors:  Rui Tao; Ibrahim M Shokry; John J Callanan
Journal:  Ann Forensic Res Anal       Date:  2017-03-07

3.  Effects of intracerebroventricular injections of 5-HT on systemic vascular resistances of conscious rats.

Authors:  Robin L Davisson; James N Bates; Alan Kim Johnson; Stephen J Lewis
Journal:  Microvasc Res       Date:  2014-08-14       Impact factor: 3.514

4.  Pressor effects following microinjection of 5-HT1A receptor agonists into the raphe obscurus of the anaesthetized rat.

Authors:  G H Dreteler; W Wouters; P R Saxena; A G Ramage
Journal:  Br J Pharmacol       Date:  1991-02       Impact factor: 8.739

5.  The renal functional responses to 5-HT1A receptor agonist, flesinoxan, in anaesthetized, normotensive rat.

Authors:  A L Chamienia; E J Johns
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

6.  Effects of 5-HT and 5-HT1A receptor agonists and antagonists on dorsal vagal preganglionic neurones in anaesthetized rats: an ionophoretic study.

Authors:  Y Wang; J F Jones; A G Ramage; D Jordan
Journal:  Br J Pharmacol       Date:  1995-10       Impact factor: 8.739

7.  Central administration of 5-HT activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/5-HT1C receptors to release vasopressin in anaesthetized rats.

Authors:  I K Anderson; G R Martin; A G Ramage
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

8.  Conditioned place preference induced by microinjection of 8-OH-DPAT into the dorsal or median raphe nucleus.

Authors:  P J Fletcher; Z H Ming; G A Higgins
Journal:  Psychopharmacology (Berl)       Date:  1993       Impact factor: 4.530

Review 9.  Neuroinflammation at the interface of depression and cardiovascular disease: Evidence from rodent models of social stress.

Authors:  Julie E Finnell; Susan K Wood
Journal:  Neurobiol Stress       Date:  2016-05-04
  9 in total

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