OBJECTIVES: To elucidate potential mechanisms for the clarithromycin-induced excess mortality observed in the CLARICOR trial during 2.6 year follow-up of patients with stable coronary artery disease. METHODS: Cox analyses using out-of-hospital death as a proxy for sudden death compared to in-hospital (nonsudden) death. RESULT: In 100 of 189 (53%) cardiovascular (CV) deaths in which it was possible to examine the question, there was a strong association between place of death and the classification of CV death as sudden or not-sudden. The excess mortality in the clarithromycin group was confined to sudden CV death in patients not on statins at trial entry (HR: 2.61, 95% CI: 1.69-4.05, p < 0.0005). Other categories of deaths showed no marked drug-placebo difference. CONCLUSIONS: Short-term clarithromycin administration was significantly associated with increased risk of sudden CV death in stable coronary heart disease patients not using statins.
OBJECTIVES: To elucidate potential mechanisms for the clarithromycin-induced excess mortality observed in the CLARICOR trial during 2.6 year follow-up of patients with stable coronary artery disease. METHODS:Cox analyses using out-of-hospital death as a proxy for sudden death compared to in-hospital (nonsudden) death. RESULT: In 100 of 189 (53%) cardiovascular (CV) deaths in which it was possible to examine the question, there was a strong association between place of death and the classification of CV death as sudden or not-sudden. The excess mortality in the clarithromycin group was confined to sudden CV death in patients not on statins at trial entry (HR: 2.61, 95% CI: 1.69-4.05, p < 0.0005). Other categories of deaths showed no marked drug-placebo difference. CONCLUSIONS: Short-term clarithromycin administration was significantly associated with increased risk of sudden CV death in stable coronary heart diseasepatients not using statins.
Authors: Malene Plejdrup Hansen; Anna M Scott; Amanda McCullough; Sarah Thorning; Jeffrey K Aronson; Elaine M Beller; Paul P Glasziou; Tammy C Hoffmann; Justin Clark; Chris B Del Mar Journal: Cochrane Database Syst Rev Date: 2019-01-18
Authors: An Mt Van Nuffel; Vidula Sukhatme; Pan Pantziarka; Lydie Meheus; Vikas P Sukhatme; Gauthier Bouche Journal: Ecancermedicalscience Date: 2015-02-24
Authors: Per Winkel; Janus Christian Jakobsen; Jørgen Hilden; Theis Lange; Gorm Boje Jensen; Erik Kjøller; Ahmad Sajadieh; Jens Kastrup; Hans Jørn Kolmos; Anders Larsson; Johan Ärnlöv; Christian Gluud Journal: Diagn Progn Res Date: 2017-03-29
Authors: Jakob Schroder; Janus Christian Jakobsen; Per Winkel; Jørgen Hilden; Gorm Boje Jensen; Ahmad Sajadieh; Anders Larsson; Johan Ärnlöv; Marina Harutyunyan; Julia S Johansen; Erik Kjøller; Christian Gluud; Jens Kastrup Journal: J Am Heart Assoc Date: 2020-03-02 Impact factor: 5.501
Authors: Per Winkel; Janus Christian Jakobsen; Jørgen Hilden; Gorm Boje Jensen; Erik Kjøller; Ahmad Sajadieh; Jens Kastrup; Hans Jørn Kolmos; Kasper Karmark Iversen; Mette Bjerre; Anders Larsson; Johan Ärnlöv; Christian Gluud Journal: BMJ Open Date: 2020-08-20 Impact factor: 2.692
Authors: Per Winkel; Janus Christian Jakobsen; Jørgen Hilden; Gorm Jensen; Erik Kjøller; Ahmad Sajadieh; Jens Kastrup; Hans Jørn Kolmos; Anders Larsson; Johan Ärnlöv; Christian Gluud Journal: Open Heart Date: 2018-09-05
Authors: Erik Nilsson; Jens Kastrup; Ahmad Sajadieh; Gorm Boje Jensen; Erik Kjøller; Hans Jørn Kolmos; Jonas Wuopio; Christoph Nowak; Anders Larsson; Janus Christian Jakobsen; Per Winkel; Christian Gluud; Kasper K Iversen; Johan Ärnlöv; Axel C Carlsson Journal: J Clin Med Date: 2020-01-18 Impact factor: 4.241