Literature DB >> 21447875

Transmission of integrase strand-transfer inhibitor multidrug-resistant HIV-1: case report and response to raltegravir-containing antiretroviral therapy.

Benjamin Young1, Signe Fransen, Kenneth S Greenberg, Amy Thomas, Sharon Martens, Marty St Clair, Christos J Petropoulos, Belinda Ha.   

Abstract

We report the case of an integrase strand-transfer inhibitor (INI)-resistant and four-drug-class-resistant HIV-1 variant infecting an antiretroviral therapy-naive man. The virus harboured INI drug resistance substitutions (Q148H and G140S) along with multiple reverse transcriptase and protease inhibitor resistance mutations. This case illustrates an emerging need to consider the possibility of acquired INI resistance among newly diagnosed treatment-naive individuals harbouring multidrug-resistant HIV-1.

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Year:  2011        PMID： 21447875     DOI： 10.3851/IMP1748

Source DB:  PubMed          Journal:  Antivir Ther        ISSN： 1359-6535


  27 in total

Review 1.  Drug resistance in HIV-1.

Authors:  Daniel R Kuritzkes
Journal:  Curr Opin Virol       Date:  2011-12       Impact factor: 7.090

2.  Raltegravir in HIV-1 infection: Safety and Efficacy in Treatment-naïve Patients.

Authors:  Krishan K Pandey
Journal:  Clin Med Rev Ther       Date:  2011-12-20

3.  Transmitted resistance to HIV integrase strand-transfer inhibitors: right on schedule.

Authors:  Christopher B Hurt
Journal:  Antivir Ther       Date:  2011

4.  Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance.

Authors:  Philip L Tzou; Soo-Yon Rhee; Diane Descamps; Dana S Clutter; Bradley Hare; Orna Mor; Maxime Grude; Neil Parkin; Michael R Jordan; Silvia Bertagnolio; Jonathan M Schapiro; P Richard Harrigan; Anna Maria Geretti; Anne-Geneviève Marcelin; Robert W Shafer
Journal:  J Antimicrob Chemother       Date:  2020-01-01       Impact factor: 5.790

5.  Efficacy of a nucleoside-sparing regimen of darunavir/ritonavir plus raltegravir in treatment-naive HIV-1-infected patients (ACTG A5262).

Authors:  Babafemi Taiwo; Lu Zheng; Sebastien Gallien; Roy M Matining; Daniel R Kuritzkes; Cara C Wilson; Baiba I Berzins; Edward P Acosta; Barbara Bastow; Peter S Kim; Joseph J Eron
Journal:  AIDS       Date:  2011-11-13       Impact factor: 4.177

6.  Should We Be Testing for Baseline Integrase Resistance in Patients Newly Diagnosed With Human Immunodeficiency Virus?

Authors:  Yiannis Koullias; Paul E Sax; Naomi F Fields; Rochelle P Walensky; Emily P Hyle
Journal:  Clin Infect Dis       Date:  2017-10-15       Impact factor: 9.079

7.  Analysis of HIV Integrase Resistance in Black Men Who Have Sex with Men in the United States.

Authors:  Iris Chen; Yinfeng Zhang; Vanessa Cummings; Gavin A Cloherty; Matthew Connor; Geetha Beauchamp; Sam Griffith; Scott Rose; Joel Gallant; Hyman M Scott; Steven Shoptaw; Carlos Del Rio; Irene Kuo; Sharon Mannheimer; Hong-Van Tieu; Christopher B Hurt; Sheldon D Fields; Darrell P Wheeler; Kenneth H Mayer; Beryl A Koblin; Susan H Eshleman
Journal:  AIDS Res Hum Retroviruses       Date:  2017-04-06       Impact factor: 2.205

8.  Prevalence of Transmitted HIV Drug Resistance Among Recently Infected Persons in San Diego, CA 1996-2013.

Authors:  Theppharit Panichsillapakit; Davey M Smith; Joel O Wertheim; Douglas D Richman; Susan J Little; Sanjay R Mehta
Journal:  J Acquir Immune Defic Syndr       Date:  2016-02-01       Impact factor: 3.731

9.  Efficacy and tolerability of 3 nonnucleoside reverse transcriptase inhibitor-sparing antiretroviral regimens for treatment-naive volunteers infected with HIV-1: a randomized, controlled equivalence trial.

Authors:  Jeffrey L Lennox; Raphael J Landovitz; Heather J Ribaudo; Ighovwerha Ofotokun; Lumine H Na; Catherine Godfrey; Daniel R Kuritzkes; Manish Sagar; Todd T Brown; Susan E Cohn; Grace A McComsey; Francesca Aweeka; Carl J Fichtenbaum; Rachel M Presti; Susan L Koletar; David W Haas; Kristine B Patterson; Constance A Benson; Bryan P Baugh; Randi Y Leavitt; James F Rooney; Daniel Seekins; Judith S Currier
Journal:  Ann Intern Med       Date:  2014-10-07       Impact factor: 25.391

10.  Resistance to HIV integrase strand transfer inhibitors among clinical specimens in the United States, 2009-2012.

Authors:  Christopher B Hurt; Joseph Sebastian; Charles B Hicks; Joseph J Eron
Journal:  Clin Infect Dis       Date:  2013-10-21       Impact factor: 9.079
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