Literature DB >> 21447121

Sulphilimine cross-links in Goodpasture's disease.

R Vanacore1, V Pedchenko, G Bhave, B G Hudson.   

Abstract

The sulphilimine cross-link of the Goodpasture (GP) autoantigen is a novel molecular mechanism (structural constraint) for conferring immune privilege to a site which otherwise is susceptible to structural changes that induce an immunogenic and pathogenic conformation. Perturbation of the assembly or cleavage of the sulphilimine cross-links could be a key factor in the aetiology of Goodpasture's disease in susceptible individuals.
© 2011 The Authors; Clinical and Experimental Immunology © 2011 British Society for Immunology.

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Year:  2011        PMID： 21447121      PMCID： PMC3095855          DOI： 10.1111/j.1365-2249.2011.04356.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  10 in total

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Authors:  R G Phelps; A J Rees
Journal:  Kidney Int       Date:  1999-11       Impact factor: 10.612

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Journal:  Science       Date:  2009-09-04       Impact factor: 47.728
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  6 in total

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