| Literature DB >> 21446758 |
Yukio Fujiwara1, Akinori Hayashida, Keiichiro Tsurushima, Ryoji Nagai, Makiko Yoshitomi, Norika Daiguji, Naomi Sakashita, Motohiro Takeya, Sachiko Tsukamoto, Tsuyoshi Ikeda.
Abstract
Because foam cell formation in macrophages is believed to play an essential role in the progression of early atherosclerotic lesions in vivo, prevention of foam cell formation is considered to be one of the major targets for the treatment of atherosclerosis. The present study examined the inhibitory effect of 50 crude plant extracts on foam cell formation. Among those crude extracts, Zizyphi Fructus (ZF) and Zizyphi Semen (ZS) extracts significantly inhibited the foam cell formation induced by acetylated LDL. Furthermore, triterpenoids such as oleanonic acid, pomolic acid, and pomonic acid were the major active compounds, and triterpenoids containing a carboxylic acid at C-28 play an important role in the inhibitory effect on foam cell formation in human macrophages. These data suggest that triterpenoids in Zizyphus jujuba , the plant source of ZF and ZS, may therefore be useful for the prevention of atherosclerosis.Entities:
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Year: 2011 PMID： 21446758 DOI： 10.1021/jf200193r
Source DB: PubMed Journal: J Agric Food Chem ISSN： 0021-8561 Impact factor: 5.279