Literature DB >> 21445623

Molecular cloning, expression, and regulation of goose leptin receptor gene in adipocytes.

Fang Wang1, Lizhi Lu, Hao Yuan, Yong Tian, Jinjun Li, Junda Shen, Zhengrong Tao, Yan Fu.   

Abstract

A full-length cDNA encoding the goose (Anser anser) leptin receptor (LEPR) was cloned and sequenced. The goose LEPR gene encodes a 1,156-amino acid protein containing a signal peptide, a single transmembrane domain and specific motifs involving putative leptin-binding and signal transduction. The deduced goose LEPR protein shows more than 90% identity to duck and 75% identity to chicken and turkey. Quantitative real-time analysis reveals that the goose LEPR is predominantly expressed in brain. The expression of LEPR in goose adipocytes can be up-regulated by oleic acid in vitro. Moreover, the expression levels of genes, which have been demonstrated to be related to adipocyte differentiation, are down-regulated in LEPR-knockdown adipocytes, indicating LEPR's potential role in adipocyte differentiation in goose.

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Year:  2011        PMID： 21445623     DOI： 10.1007/s11010-011-0795-4

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  19 in total

1.  Crossing the border: developmental regulation of leptin transport to the brain.

Authors:  Sebastien G Bouret
Journal:  Endocrinology       Date:  2008-03       Impact factor: 4.736

2.  Evidence for leptin receptor isoforms heteromerization at the cell surface.

Authors:  Johan Bacart; Audrey Leloire; Angélique Levoye; Philippe Froguel; Ralf Jockers; Cyril Couturier
Journal:  FEBS Lett       Date:  2010-03-27       Impact factor: 4.124

3.  A short form of leptin receptor performs signal transduction.

Authors:  T Murakami; T Yamashita; M Iida; M Kuwajima; K Shima
Journal:  Biochem Biophys Res Commun       Date:  1997-02-03       Impact factor: 3.575

4.  Mapping of the leptin receptor gene (LEPR) to chicken chromosome 8.

Authors:  I C Dunn; T Boswell; M Friedman-Einat; Y Eshdat; D W Burt; I R Paton
Journal:  Anim Genet       Date:  2000-08       Impact factor: 3.169

5.  Leptin and leptin receptor expression in skeletal muscle and adipose tissue in response to in vivo porcine somatotropin treatment.

Authors:  T G Ramsay; M P Richards
Journal:  J Anim Sci       Date:  2005-11       Impact factor: 3.159

6.  Expression of leptin receptor gene in developing and adult zebrafish.

Authors:  Qin Liu; Yun Chen; Donald Copeland; Hope Ball; Robert J Duff; Briana Rockich; Richard L Londraville
Journal:  Gen Comp Endocrinol       Date:  2009-11-24       Impact factor: 2.822

7.  Leptin and insulin downregulate leptin receptor gene expression in chicken-derived leghorn male hepatoma cells.

Authors:  S Cassy; M Derouet; S Crochet; S Dridi; M Taouis
Journal:  Poult Sci       Date:  2003-10       Impact factor: 3.352

8.  Hormonal regulation of leptin receptor expression in primary cultures of porcine hepatocytes.

Authors:  T J Caperna; A E Shannon; S M Poch; W M Garrett; M P Richards
Journal:  Domest Anim Endocrinol       Date:  2005-04-07       Impact factor: 2.290

9.  Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.

Authors:  Mirko Riolfi; Rita Ferla; Luis Del Valle; Sergio Piña-Oviedo; Laura Scolaro; Rocco Micciolo; Micol Guidi; Marianna Terrasi; Gian Luigi Cetto; Eva Surmacz
Journal:  Brain Pathol       Date:  2009-08-06       Impact factor: 6.508

10.  Leptin receptor in the chicken ovary: potential involvement in ovarian dysfunction of ad libitum-fed broiler breeder hens.

Authors:  Sandrine Cassy; Sonia Metayer; Sabine Crochet; Nicole Rideau; Anne Collin; Sophie Tesseraud
Journal:  Reprod Biol Endocrinol       Date:  2004-10-08       Impact factor: 5.211
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  4 in total

1.  Expression pattern of L-FABP gene in different tissues and its regulation of fat metabolism-related genes in duck.

Authors:  Jun He; Yong Tian; Jinjun Li; Junda Shen; Zhengrong Tao; Yan Fu; Dong Niu; Lizhi Lu
Journal:  Mol Biol Rep       Date:  2012-10-13       Impact factor: 2.316

2.  Isolation, culture and differentiation of duck (Anas platyrhynchos) preadipocytes.

Authors:  Fang Ding; Qing-Qing Li; Le Li; Chao Gan; Xin Yuan; Hua Gou; Hua He; Chun-Chun Han; Ji-Wen Wang
Journal:  Cytotechnology       Date:  2014-04-03       Impact factor: 2.058

3.  The differentiation of preadipocytes and gene expression related to adipogenesis in ducks (Anas platyrhynchos).

Authors:  Shasha Wang; Yang Zhang; Qi Xu; Xiaoya Yuan; Wangcheng Dai; Xiaokun Shen; Zhixiu Wang; Guobin Chang; Zhiquan Wang; Guohong Chen
Journal:  PLoS One       Date:  2018-05-17       Impact factor: 3.240

4.  Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors.

Authors:  Natália R T Amorim; Tatiana Luna-Gomes; Marcos Gama-Almeida; Glaucia Souza-Almeida; Claudio Canetti; Bruno L Diaz; Peter F Weller; Patricia Torres Bozza; Clarissa M Maya-Monteiro; Christianne Bandeira-Melo
Journal:  Front Immunol       Date:  2018-09-20       Impact factor: 7.561
  4 in total

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