Literature DB >> 21445072

DNMT3A mutations in acute myeloid leukemia.

Mrinal Y Shah1, Jonathan D Licht.   

Abstract

New studies reveal that 20% of individuals with acute myeloid leukemia harbor somatic mutations in DNMT3A (encoding DNA methyltransferase 3A). Although these leukemias have some gene expression and DNA methylation changes, a direct link between mutant DNMT3A, epigenetic changes and pathogenesis remains to be established.

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Year:  2011        PMID： 21445072     DOI： 10.1038/ng0411-289

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  15 in total

1.  DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Authors:  Ann-Marie Bröske; Lena Vockentanz; Shabnam Kharazi; Matthew R Huska; Elena Mancini; Marina Scheller; Christiane Kuhl; Andreas Enns; Marco Prinz; Rudolf Jaenisch; Claus Nerlov; Achim Leutz; Miguel A Andrade-Navarro; Sten Eirik W Jacobsen; Frank Rosenbauer
Journal:  Nat Genet       Date:  2009-10-04       Impact factor: 38.330

2.  Array-based genomic resequencing of human leukemia.

Authors:  Y Yamashita; J Yuan; I Suetake; H Suzuki; Y Ishikawa; Y L Choi; T Ueno; M Soda; T Hamada; H Haruta; S Takada; Y Miyazaki; H Kiyoi; E Ito; T Naoe; M Tomonaga; M Toyota; S Tajima; A Iwama; H Mano
Journal:  Oncogene       Date:  2010-04-19       Impact factor: 9.867

Review 3.  The epigenomics of cancer.

Authors:  Peter A Jones; Stephen B Baylin
Journal:  Cell       Date:  2007-02-23       Impact factor: 41.582

4.  DNMT3A mutations in acute myeloid leukemia.

Authors:  Timothy J Ley; Li Ding; Matthew J Walter; Michael D McLellan; Tamara Lamprecht; David E Larson; Cyriac Kandoth; Jacqueline E Payton; Jack Baty; John Welch; Christopher C Harris; Cheryl F Lichti; R Reid Townsend; Robert S Fulton; David J Dooling; Daniel C Koboldt; Heather Schmidt; Qunyuan Zhang; John R Osborne; Ling Lin; Michelle O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Vincent J Magrini; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Joshua J Conyers; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd Wylie; Jason Walker; Joelle Kalicki; Mark A Watson; Sharon Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Peter Westervelt; Michael H Tomasson; Daniel C Link; Timothy A Graubert; John F DiPersio; Elaine R Mardis; Richard K Wilson
Journal:  N Engl J Med       Date:  2010-11-10       Impact factor: 91.245

5.  Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1.

Authors:  Jharna Datta; Kalpana Ghoshal; Sudarshana M Sharma; Shoji Tajima; Samson T Jacob
Journal:  J Cell Biochem       Date:  2003-04-01       Impact factor: 4.429

6.  Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia.

Authors:  Xiao-Jing Yan; Jie Xu; Zhao-Hui Gu; Chun-Ming Pan; Gang Lu; Yang Shen; Jing-Yi Shi; Yong-Mei Zhu; Lin Tang; Xiao-Wei Zhang; Wen-Xue Liang; Jian-Qing Mi; Huai-Dong Song; Ke-Qin Li; Zhu Chen; Sai-Juan Chen
Journal:  Nat Genet       Date:  2011-03-13       Impact factor: 38.330

7.  Comprehensive methylome map of lineage commitment from haematopoietic progenitors.

Authors:  Hong Ji; Lauren I R Ehrlich; Jun Seita; Peter Murakami; Akiko Doi; Paul Lindau; Hwajin Lee; Martin J Aryee; Rafael A Irizarry; Kitai Kim; Derrick J Rossi; Matthew A Inlay; Thomas Serwold; Holger Karsunky; Lena Ho; George Q Daley; Irving L Weissman; Andrew P Feinberg
Journal:  Nature       Date:  2010-08-15       Impact factor: 49.962

8.  Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Authors:  Maria E Figueroa; Omar Abdel-Wahab; Chao Lu; Patrick S Ward; Jay Patel; Alan Shih; Yushan Li; Neha Bhagwat; Aparna Vasanthakumar; Hugo F Fernandez; Martin S Tallman; Zhuoxin Sun; Kristy Wolniak; Justine K Peeters; Wei Liu; Sung E Choe; Valeria R Fantin; Elisabeth Paietta; Bob Löwenberg; Jonathan D Licht; Lucy A Godley; Ruud Delwel; Peter J M Valk; Craig B Thompson; Ross L Levine; Ari Melnick
Journal:  Cancer Cell       Date:  2010-12-09       Impact factor: 38.585

9.  DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells.

Authors:  Jennifer J Trowbridge; Jonathan W Snow; Jonghwan Kim; Stuart H Orkin
Journal:  Cell Stem Cell       Date:  2009-10-02       Impact factor: 24.633

10.  De novo DNA methyltransferase is essential for self-renewal, but not for differentiation, in hematopoietic stem cells.

Authors:  Yuko Tadokoro; Hideo Ema; Masaki Okano; En Li; Hiromitsu Nakauchi
Journal:  J Exp Med       Date:  2007-04-09       Impact factor: 14.307
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  24 in total

1.  Mutations in DNA methyltransferase (DNMT3A) observed in acute myeloid leukemia patients disrupt processive methylation.

Authors:  Celeste Holz-Schietinger; Doug M Matje; Norbert O Reich
Journal:  J Biol Chem       Date:  2012-06-21       Impact factor: 5.157

2.  Selective demethylation and altered gene expression are associated with ICF syndrome in human-induced pluripotent stem cells and mesenchymal stem cells.

Authors:  Kevin Huang; Zhourui Wu; Zhenshan Liu; Ganlu Hu; Juehua Yu; Kai H Chang; Kee-Pyo Kim; Thuc Le; Kym F Faull; Nagesh Rao; Andrew Gennery; Zhigang Xue; Cun-Yu Wang; Matteo Pellegrini; Guoping Fan
Journal:  Hum Mol Genet       Date:  2014-07-15       Impact factor: 6.150

3.  DNA methyltransferase 3a hot-spot locus is not mutated in pediatric patients affected by acute myeloid or T-cell acute lymphoblastic leukemia: an Italian study.

Authors:  Maddalena Paganin; Martina Pigazzi; Silvia Bresolin; Riccardo Masetti; Franca Fagioli; Sabina Chiaretti; Giovanni Cazzaniga; Franco Locatelli; Andrea Pession; Geertruy te Kronnie; Giuseppe Basso
Journal:  Haematologica       Date:  2011-08-31       Impact factor: 9.941

4.  miR-199b-5p directly targets PODXL and DDR1 and decreased levels of miR-199b-5p correlate with elevated expressions of PODXL and DDR1 in acute myeloid leukemia.

Authors:  Amanda J Favreau; Erin L Cross; Pradeep Sathyanarayana
Journal:  Am J Hematol       Date:  2012-02-28       Impact factor: 10.047

Review 5.  Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation.

Authors:  Hao Wu; Yi Zhang
Journal:  Genes Dev       Date:  2011-12-01       Impact factor: 11.361

Review 6.  The curious origins of angioimmunoblastic T-cell lymphoma.

Authors:  José R Cortés; Teresa Palomero
Journal:  Curr Opin Hematol       Date:  2016-07       Impact factor: 3.284

7.  Oligomerization of DNMT3A controls the mechanism of de novo DNA methylation.

Authors:  Celeste Holz-Schietinger; Douglas M Matje; Madeleine Flexer Harrison; Norbert O Reich
Journal:  J Biol Chem       Date:  2011-10-06       Impact factor: 5.157

Review 8.  The role of DNA methylation in aging, rejuvenation, and age-related disease.

Authors:  Adiv A Johnson; Kemal Akman; Stuart R G Calimport; Daniel Wuttke; Alexandra Stolzing; João Pedro de Magalhães
Journal:  Rejuvenation Res       Date:  2012-10       Impact factor: 4.663

9.  A panoramic view of acute myeloid leukemia.

Authors:  Sai-Juan Chen; Yang Shen; Zhu Chen
Journal:  Nat Genet       Date:  2013-06       Impact factor: 38.330

Review 10.  Making it or breaking it: DNA methylation and genome integrity.

Authors:  Anusha Sriraman; Turja K Debnath; Blerta Xhemalce; Kyle M Miller
Journal:  Essays Biochem       Date:  2020-10-26       Impact factor: 8.000
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