BACKGROUND: Although fever is recognised as a major presentation symptom at Emergency Departments (EDs) and is often used as a rationale for the institution of antibiotics, few studies describing patients with fever as the sole inclusion criterion at the ED of a general hospital have been performed. The objective of this study is to describe epidemiology of non-surgical febrile patients at the ED and to identify risk factors for adverse outcome. METHODS: Blood, sputum, urine and faeces cultures, urine sediments and throat swaps for viral diagnostics were obtained from febrile ED patients. Outcome parameters were bacterial/viral infection, non-bacterial/non-viral infection, non-infectious febrile disease; mortality, hospital admission, admission to the intensive care unit (ICU) and length of hospital stay. RESULTS: 213 Patients were included (87.8% were hospitalised, 8.5% were admitted to ICU, 4.2% died). In 75 patients (35.2%), bacterial infection was confirmed; in 78 patients (36.6%) bacterial infection was suspected. In nine patients (4.2%), viral diagnosis was confirmed; in six patients (2.8%), a viral condition was suspected. The most frequently encountered infection was bacterial pneumonia (58 patients, 27.2%). Only older age was correlated with mortality (ρ=0.176, p=0.01). CONCLUSION: A majority of the febrile patients were admitted to the hospital, mostly for bacterial infection. An overall mortality rate of 4.2% was registered. Only a few risk factors for adverse outcome could be identified in this cohort. Overall, the outcome of patients presenting with fever at the ED is rather benign.
BACKGROUND: Although fever is recognised as a major presentation symptom at Emergency Departments (EDs) and is often used as a rationale for the institution of antibiotics, few studies describing patients with fever as the sole inclusion criterion at the ED of a general hospital have been performed. The objective of this study is to describe epidemiology of non-surgical febrile patients at the ED and to identify risk factors for adverse outcome. METHODS: Blood, sputum, urine and faeces cultures, urine sediments and throat swaps for viral diagnostics were obtained from febrile ED patients. Outcome parameters were bacterial/viral infection, non-bacterial/non-viral infection, non-infectious febrile disease; mortality, hospital admission, admission to the intensive care unit (ICU) and length of hospital stay. RESULTS: 213 Patients were included (87.8% were hospitalised, 8.5% were admitted to ICU, 4.2% died). In 75 patients (35.2%), bacterial infection was confirmed; in 78 patients (36.6%) bacterial infection was suspected. In nine patients (4.2%), viral diagnosis was confirmed; in six patients (2.8%), a viral condition was suspected. The most frequently encountered infection was bacterial pneumonia (58 patients, 27.2%). Only older age was correlated with mortality (ρ=0.176, p=0.01). CONCLUSION: A majority of the febrile patients were admitted to the hospital, mostly for bacterial infection. An overall mortality rate of 4.2% was registered. Only a few risk factors for adverse outcome could be identified in this cohort. Overall, the outcome of patients presenting with fever at the ED is rather benign.
Authors: Thien Phu Do; Angelique Remmers; Henrik Winther Schytz; Christoph Schankin; Sarah E Nelson; Mark Obermann; Jakob Møller Hansen; Alexandra J Sinclair; Andreas R Gantenbein; Guus G Schoonman Journal: Neurology Date: 2018-12-26 Impact factor: 11.800
Authors: Christian S Marchello; Ariella P Dale; Sruti Pisharody; Matthew P Rubach; John A Crump Journal: Antimicrob Agents Chemother Date: 2019-12-20 Impact factor: 5.191
Authors: Simon Leigh; Bimal Mehta; Lillian Dummer; Harriet Aird; Sinead McSorley; Venessa Oseyenum; Anna Cumbers; Mary Ryan; Karl Edwardson; Phil Johnston; Jude Robinson; Frans Coenen; David Taylor-Robinson; Louis W Niessen; Enitan D Carrol Journal: Br J Gen Pract Date: 2020-12-28 Impact factor: 5.386
Authors: Yuri van der Does; Maarten Limper; Stephanie C E Schuit; Marten J Poley; Joost van Rosmalen; Christian Ramakers; Peter Patka; Eric C M van Gorp; Pleunie P M Rood Journal: BMC Emerg Med Date: 2016-04-06
Authors: Dayle Sampson; Thomas D Yager; Brian Fox; Laura Shallcross; Leo McHugh; Therese Seldon; Antony Rapisarda; Roslyn A Hendriks; Richard B Brandon; Krupa Navalkar; Nandi Simpson; Sian Stafford; Eliza Gil; Cristina Venturini; Evi Tsaliki; Jennifer Roe; Benjamin Chain; Mahdad Noursadeghi Journal: BMC Med Date: 2020-07-21 Impact factor: 8.775
Authors: Simon Leigh; Alison Grant; Nicola Murray; Brian Faragher; Henal Desai; Samantha Dolan; Naeema Cabdi; James B Murray; Yasmin Rejaei; Stephanie Stewart; Karl Edwardson; Jason Dean; Bimal Mehta; Shunmay Yeung; Frans Coenen; Louis W Niessen; Enitan D Carrol Journal: BMC Med Date: 2019-03-06 Impact factor: 8.775