Community-based study on psychological comorbidity in functional gastrointestinal disorder.

Functional gastrointestinal disorder (FGID) is one of the commonest digestive diseases worldwide. Current evidence supports a bio-psycho-social pathophysiological model for FGID, which underscores the importance of psychological and social factors in development of FGID. Concomitant psychological disorders, which include anxiety, depression and somatization, have been shown to be associated with FGID in both specialist and community-based studies. This suggests that the association is genuine rather than biased observation in referral centers. Furthermore, psychological distress such as depression, anxiety and phobia are strongly correlated with severity of FGID symptoms. There are biologically plausible mechanisms that support the causal role of psychological disorders in FGID. Psychological distress, in particular anxiety, can induce aggravation of visceral hyperalgesia as well as hypervigilance in FGID patients. This leads to poorer quality of life and increased utilization of healthcare service in addition to worsening of symptoms. Despite the numerous reports on the potential therapeutic value of psychotropic agents and psychological intervention, the importance of screening for concomitant psychological disorder in FGID patients has not been fully recognized in daily practice. Most FGID patients tend to have very low awareness of their mood symptoms, which lead to delayed diagnosis, deterioration of disease and unnecessary investigations. Many of these patients may be reluctant to accept the diagnosis of concomitant psychological disorders and therefore a good doctor-patient rapport and therapeutic relationship are essential for management of these patients.