Nirmala Pandeya1, David C Whiteman. 1. School of Population Health, the University of Queensland, Australia. n.pandeya1@uq.edu.au
Abstract
BACKGROUND AND AIM: To estimate the sero-prevalence of Helicobacter Pylori infection in the Australian adult population and identify determinants. METHODS: We analyzed serum samples and questionnaire data from 1355 community controls who participated in a nationwide case-control study of esophageal cancer in Australia between 2002 and 2005. We estimated the prevalence ratio and 95% confidence interval using log binomial regression models. RESULTS: The age and sex standardized sero-prevalence of H. pylori was 15.5%. The prevalence of infection varied significantly with age, ranging from 5% (< 40 years) to 32% (≥ 70 years). H. pylori infection was significantly higher among those born overseas (prevalence ratio [PR] 1.63; 95% confidence interval [CI] 1.34-1.98) compared with those born in Australia or New Zealand. H. pylori sero-prevalence was 23% higher among participants living in the lowest quartile of socio-economic areas (PR 0.77; 95%CI 0.59-0.99 for Q4 compared with Q1). H pylori serostatus was significantly inversely associated with university education (PR 0.56; 95%CI 0.38-0.83), frequent reflux symptoms (PR 0.62; 95%CI 0.42-0.91), use of proton pump inhibitor (PR 0.69; 95%CI 0.48-0.98) and use of medications for gut spasms (PR 0.48; 95%CI 0.25-0.93). H. pylori serostatus was not associated with body mass index, smoking, alcohol or physical activity. CONCLUSIONS: The prevalence of H. pylori infection in Australian adults is lower than other developed countries. H. pylori infection is most common among those living in the areas of socio-economic disadvantage or who were born overseas.
BACKGROUND AND AIM: To estimate the sero-prevalence of Helicobacter Pylori infection in the Australian adult population and identify determinants. METHODS: We analyzed serum samples and questionnaire data from 1355 community controls who participated in a nationwide case-control study of esophageal cancer in Australia between 2002 and 2005. We estimated the prevalence ratio and 95% confidence interval using log binomial regression models. RESULTS: The age and sex standardized sero-prevalence of H. pylori was 15.5%. The prevalence of infection varied significantly with age, ranging from 5% (< 40 years) to 32% (≥ 70 years). H. pylori infection was significantly higher among those born overseas (prevalence ratio [PR] 1.63; 95% confidence interval [CI] 1.34-1.98) compared with those born in Australia or New Zealand. H. pylori sero-prevalence was 23% higher among participants living in the lowest quartile of socio-economic areas (PR 0.77; 95%CI 0.59-0.99 for Q4 compared with Q1). H pylori serostatus was significantly inversely associated with university education (PR 0.56; 95%CI 0.38-0.83), frequent reflux symptoms (PR 0.62; 95%CI 0.42-0.91), use of proton pump inhibitor (PR 0.69; 95%CI 0.48-0.98) and use of medications for gut spasms (PR 0.48; 95%CI 0.25-0.93). H. pylori serostatus was not associated with body mass index, smoking, alcohol or physical activity. CONCLUSIONS: The prevalence of H. pylori infection in Australian adults is lower than other developed countries. H. pylori infection is most common among those living in the areas of socio-economic disadvantage or who were born overseas.
Authors: David C Whiteman; Penelope M Webb; Adele C Green; Rachel E Neale; Lin Fritschi; Christopher J Bain; D Max Parkin; Louise F Wilson; Catherine M Olsen; Christina M Nagle; Nirmala Pandeya; Susan J Jordan; Annika Antonsson; Bradley J Kendall; Maria Celia B Hughes; Torukiri I Ibiebele; Kyoko Miura; Susan Peters; Renee N Carey Journal: Aust N Z J Public Health Date: 2015-10 Impact factor: 2.939
Authors: Annika Antonsson; Louise F Wilson; Bradley J Kendall; Christopher J Bain; David C Whiteman; Rachel E Neale Journal: Aust N Z J Public Health Date: 2015-10 Impact factor: 2.939