OBJECTIVE: To compare the executive function of patients with familial bipolar I disorder (BP-I) with a history of psychotic symptoms to their first-degree relatives and normal controls. METHODS: Three domains of executive function: response inhibition, working memory, and cognitive set shifting were assessed in 44 familial patients with a lifetime diagnosis of BP-I who had experienced psychotic symptoms, 42 of their unaffected first-degree relatives, and 47 controls. RESULTS: Bipolar disorder patients and their unaffected relatives had significantly worse scores for response inhibition compared to healthy controls. The groups did not differ in working memory or cognitive set shifting. CONCLUSIONS: Impairments in response inhibition are associated with both psychotic bipolar disorder and genetic liability for this illness. Our results indicate that deficits in this specific domain of executive functioning are a promising candidate endophenotype for psychotic bipolar disorder.
OBJECTIVE: To compare the executive function of patients with familial bipolar I disorder (BP-I) with a history of psychotic symptoms to their first-degree relatives and normal controls. METHODS: Three domains of executive function: response inhibition, working memory, and cognitive set shifting were assessed in 44 familial patients with a lifetime diagnosis of BP-I who had experienced psychotic symptoms, 42 of their unaffected first-degree relatives, and 47 controls. RESULTS:Bipolar disorderpatients and their unaffected relatives had significantly worse scores for response inhibition compared to healthy controls. The groups did not differ in working memory or cognitive set shifting. CONCLUSIONS: Impairments in response inhibition are associated with both psychotic bipolar disorder and genetic liability for this illness. Our results indicate that deficits in this specific domain of executive functioning are a promising candidate endophenotype for psychotic bipolar disorder.
Authors: Pilyoung Kim; Sarah E Jenkins; Megan E Connolly; Christen M Deveney; Stephen J Fromm; Melissa A Brotman; Eric E Nelson; Daniel S Pine; Ellen Leibenluft Journal: J Psychiatr Res Date: 2011-10-22 Impact factor: 4.791
Authors: S Kristian Hill; Alison Buchholz; Hayley Amsbaugh; James L Reilly; Leah H Rubin; James M Gold; Richard S E Keefe; Godfrey D Pearlson; Matcheri S Keshavan; Carol A Tamminga; John A Sweeney Journal: Schizophr Res Date: 2015-05-23 Impact factor: 4.939
Authors: Manpreet K Singh; Kiki D Chang; Ryan G Kelley; Manish Saggar; Allan L Reiss; Ian H Gotlib Journal: Bipolar Disord Date: 2014-06-17 Impact factor: 6.744
Authors: S Kristian Hill; James L Reilly; Michael E Ragozzino; Leah H Rubin; Jeffrey R Bishop; Ruben C Gur; Elliot S Gershon; Carol A Tamminga; Godfrey D Pearlson; Matcheri S Keshavan; Richard S E Keefe; John A Sweeney Journal: Schizophr Bull Date: 2014-09-05 Impact factor: 9.306