Literature DB >> 21443476

PCL/PEG copolymeric nanoparticles: potential nanoplatforms for anticancer agent delivery.

MaLing Gou1, XiaWei Wei, Ke Men, BiLan Wang, Feng Luo, Xia Zhao, YuQuan Wei, ZhiYong Qian.   

Abstract

Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In recent years, PCL/PEG copolymeric nanoparticles, as a potential nanoplatform for anticancer agent delivery, received increasing attention. This paper reviews PCL/PEG copolymer nanoparticles for anticancer agent delivery, including overcoming water insolubility of hydrophobic drug, targeting chemotherapeutic drug to tumor, and delivering genes, vaccines, and diagnostic agents.

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Year:  2011        PMID： 21443476     DOI： 10.2174/138945011795906642

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  26 in total

1.  Preclinical development of drug delivery systems for paclitaxel-based cancer chemotherapy.

Authors:  Feihu Wang; Michael Porter; Alexandros Konstantopoulos; Pengcheng Zhang; Honggang Cui
Journal:  J Control Release       Date:  2017-09-25       Impact factor: 9.776

2.  Enhanced antiproliferative and apoptosis effect of paclitaxel-loaded polymeric micelles against non-small cell lung cancers.

Authors:  Xiao-Ying Zhang; Yang-De Zhang
Journal:  Tumour Biol       Date:  2015-02-22

3.  Biodegradable m-PEG/PCL Core-Shell Micelles: Preparation and Characterization as a Sustained Release Formulation for Curcumin.

Authors:  Hossein Danafar; Soodabeh Davaran; Kobra Rostamizadeh; Hadi Valizadeh; Mehrdad Hamidi
Journal:  Adv Pharm Bull       Date:  2014-12-31

4.  Simulation of the In Vivo Fate of Polymeric Nanoparticles Traced by Environment-Responsive Near-Infrared Dye: A Physiologically Based Pharmacokinetic Modelling Approach.

Authors:  Lei Li; Haisheng He; Sifang Jiang; Jianping Qi; Yi Lu; Ning Ding; Hai-Shu Lin; Wei Wu; Xiaoqiang Xiang
Journal:  Molecules       Date:  2021-02-26       Impact factor: 4.411

5.  Preparation and characterization of monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) micelles for the solubilization and in vivo delivery of luteolin.

Authors:  Jin-Feng Qiu; Xiang Gao; Bi-Lan Wang; Xia-Wei Wei; Ma-Ling Gou; Ke Men; Xing-Yu Liu; Gang Guo; Zhi-Yong Qian; Mei-Juan Huang
Journal:  Int J Nanomedicine       Date:  2013-08-13

6.  Treating acute cystitis with biodegradable micelle-encapsulated quercetin.

Authors:  Bi Lan Wang; Xiang Gao; Ke Men; Jinfeng Qiu; Bowen Yang; Ma Ling Gou; Mei Juan Huang; Ning Huang; Zhi Yong Qian; Xia Zhao; Yu Quan Wei
Journal:  Int J Nanomedicine       Date:  2012-05-08

7.  Codelivery of SH-aspirin and curcumin by mPEG-PLGA nanoparticles enhanced antitumor activity by inducing mitochondrial apoptosis.

Authors:  Lin Zhou; Xingmei Duan; Shi Zeng; Ke Men; Xueyan Zhang; Li Yang; Xiang Li
Journal:  Int J Nanomedicine       Date:  2015-08-18

8.  Enhancing the anti-colon cancer activity of quercetin by self-assembled micelles.

Authors:  Guangya Xu; Huashan Shi; Laibin Ren; Hongfeng Gou; Daoyin Gong; Xiang Gao; Ning Huang
Journal:  Int J Nanomedicine       Date:  2015-03-16

9.  Efficient delivery of antigen to DCs using yeast-derived microparticles.

Authors:  Ying Pan; Xiaopeng Li; Tianyi Kang; Hui Meng; Zhouli Chen; Li Yang; Yang Wu; Yuquan Wei; Maling Gou
Journal:  Sci Rep       Date:  2015-05-29       Impact factor: 4.379

10.  Codelivery of curcumin and doxorubicin by MPEG-PCL results in improved efficacy of systemically administered chemotherapy in mice with lung cancer.

Authors:  Bi-Lan Wang; Yong-mei Shen; Qiong-wen Zhang; Yu-li Li; Min Luo; Ze Liu; Yan Li; Zhi-yong Qian; Xiang Gao; Hua-shan Shi
Journal:  Int J Nanomedicine       Date:  2013-09-24
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