OBJECTIVE: To evaluate early and long-term results of radical surgical removal of renal cell cancer (RCC) with tumor thrombus (TT) in the inferior vena cava (IVC) and right atrium (RA). METHODS: The study included five patients with RCC with TT in IVC and right atrium, operated from January 2004 to September 2009 in the Institute for Cardiovascular disease "Dedinje", Belgrade, Serbia. All patients underwent atrial and caval thrombectomy with the use of normothermic cardiopulmonary bypass (CPB) and the radical nephrectomy, by a joint cardiovascular and urological team. After the surgery, patients were evaluated every 3 months for the first year, every 6 months for the next 2 years, and yearly thereafter. The mean follow-up was 32.6 months (range: 7-67 months). RESULTS: There were no per-operative embolism and no in-hospital deaths. Two patients developed tumor recurrence during a mean time of 5 months and died within 1 year after the surgery. The three remaining patients are alive (mean follow-up: 48 months) and without the evidence of tumor recurrence or metastases. No patients received adjuvant therapy. CONCLUSIONS: Patients with RCC and the extension of TT in IVC and right atrium need a multidisciplinary surgical strategy. Atrial and caval tumor thrombectomy can be performed safely and effectively, with a low complication rate, using normothermic CPB. Long-term results are promising; however, larger prospective multicentre studies are necessary.
OBJECTIVE: To evaluate early and long-term results of radical surgical removal of renal cell cancer (RCC) with tumor thrombus (TT) in the inferior vena cava (IVC) and right atrium (RA). METHODS: The study included five patients with RCC with TT in IVC and right atrium, operated from January 2004 to September 2009 in the Institute for Cardiovascular disease "Dedinje", Belgrade, Serbia. All patients underwent atrial and caval thrombectomy with the use of normothermic cardiopulmonary bypass (CPB) and the radical nephrectomy, by a joint cardiovascular and urological team. After the surgery, patients were evaluated every 3 months for the first year, every 6 months for the next 2 years, and yearly thereafter. The mean follow-up was 32.6 months (range: 7-67 months). RESULTS: There were no per-operative embolism and no in-hospital deaths. Two patients developed tumor recurrence during a mean time of 5 months and died within 1 year after the surgery. The three remaining patients are alive (mean follow-up: 48 months) and without the evidence of tumor recurrence or metastases. No patients received adjuvant therapy. CONCLUSIONS:Patients with RCC and the extension of TT in IVC and right atrium need a multidisciplinary surgical strategy. Atrial and caval tumor thrombectomy can be performed safely and effectively, with a low complication rate, using normothermic CPB. Long-term results are promising; however, larger prospective multicentre studies are necessary.
Authors: J C Nesbitt; E R Soltero; C P Dinney; G L Walsh; D S Schrump; D A Swanson; L L Pisters; K D Willis; J B Putnam Journal: Ann Thorac Surg Date: 1997-06 Impact factor: 4.330
Authors: Erica H Lambert; Phillip M Pierorazio; Ahmad Shabsigh; Carl A Olsson; Mitchell C Benson; James M McKiernan Journal: Urology Date: 2007-06 Impact factor: 2.649
Authors: Paul Sweeney; Christopher G Wood; Louis L Pisters; Joel W Slaton; Ara Vaporciyan; Mark Munsell; Scott Carpenter; Joe Putnam; Stephen G Swisher; Garret Walsh; David Swanson; Colin P N Dinney Journal: Urol Oncol Date: 2003 Sep-Oct Impact factor: 3.498
Authors: Robert Sobczyński; Tomasz Golabek; Mikolaj Przydacz; Tomasz Wiatr; Jakub Bukowczan; Jerzy Sadowski; Piotr Chłosta Journal: Cent European J Urol Date: 2015-08-21