Literature DB >> 2144234

Linkage of c-Harvey-ras-1 and INS DNA markers to unipolar depression and alcoholism is ruled out in 18 families.

R B Wesner1, V L Tanna, P J Palmer, R J Goedken, R R Crowe, G Winokur.   

Abstract

Eighteen families informative for c-Harvey-ras-1 and INS DNA markers were tested for linkage to unipolar depression and alcoholism. No evidence of linkage was found between these DNA markers and the disorders observed in the families. This study fails to replicate the Old Order Amish Study and suggests that a significant degree of genetic heterogeneity may be present among psychiatric disorders.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2144234     DOI： 10.1007/bf01734541

Source DB:  PubMed          Journal:  Eur Arch Psychiatry Neurol Sci        ISSN： 0175-758X


  18 in total

1.  The effect of co-morbidity and penetrance estimation on the outcome of linkage analysis in a bipolar family.

Authors:  R B Wesner; W Scheftner; P J Palmer; R R Crowe; G Winokur
Journal:  Biol Psychiatry       Date:  1990-01-15       Impact factor: 13.382

2.  Evidence against linkage of schizophrenia to markers on chromosome 5 in a northern Swedish pedigree.

Authors:  J L Kennedy; L A Giuffra; H W Moises; L L Cavalli-Sforza; A J Pakstis; J R Kidd; C M Castiglione; B Sjogren; L Wetterberg; K K Kidd
Journal:  Nature       Date:  1988-11-10       Impact factor: 49.962

3.  Affective illness in veteran twins: a diagnostic review.

Authors:  M G Allen; S Cohen; W Pollin; S I Greenspan
Journal:  Am J Psychiatry       Date:  1974-11       Impact factor: 18.112

4.  Depression spectrum disease: description and family study.

Authors:  G Winokur
Journal:  Compr Psychiatry       Date:  1972-01       Impact factor: 3.735

5.  Depressive disease: classification and clinical characteristics.

Authors:  M Baker; J Dorzab; G Winokur; R J Cadoret
Journal:  Compr Psychiatry       Date:  1971-07       Impact factor: 3.735

6.  A family study of familial positive vs. familial negative alcoholics.

Authors:  B L Cook; G Winokur
Journal:  J Nerv Ment Dis       Date:  1985-03       Impact factor: 2.254

7.  The development and validity of familial subtypes in primary unipolar depression.

Authors:  G Winokur
Journal:  Pharmacopsychiatria       Date:  1982-07

8.  Diagnostic criteria for use in psychiatric research.

Authors:  J P Feighner; E Robins; S B Guze; R A Woodruff; G Winokur; R Munoz
Journal:  Arch Gen Psychiatry       Date:  1972-01

9.  Molecular genetic evidence for heterogeneity in manic depression.

Authors:  S Hodgkinson; R Sherrington; H Gurling; R Marchbanks; S Reeders; J Mallet; M McInnis; H Petursson; J Brynjolfsson
Journal:  Nature       Date:  1987 Feb 26-Mar 4       Impact factor: 49.962

10.  A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands.

Authors:  E S Gershon; J Hamovit; J J Guroff; E Dibble; J F Leckman; W Sceery; S D Targum; J I Nurnberger; L R Goldin; W E Bunney
Journal:  Arch Gen Psychiatry       Date:  1982-10
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.