Literature DB >> 21442009

Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition.

Xiaoguang Lei1, Samuel J Danishefsky.   

Abstract

The highly efficient synthesis of a novel heat shock protein 90 (Hsp90)-based anticancer agent, triazole-cycloproparadicicol (5), is described. The key step involves a fragment coupling using "click chemistry." The preliminary biological evaluation of triazole-cycloproparadicicol is also reported.

Entities:  

Year:  2008        PMID： 21442009      PMCID： PMC3062907          DOI： 10.1002/adsc.200800187

Source DB:  PubMed          Journal:  Adv Synth Catal        ISSN： 1615-4150            Impact factor:   5.837


  20 in total

1.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions.

Authors:  Hartmuth C. Kolb; M. G. Finn; K. Barry Sharpless
Journal:  Angew Chem Int Ed Engl       Date:  2001-06-01       Impact factor: 15.336

2.  Targeting of the protein chaperone, HSP90, by the transformation suppressing agent, radicicol.

Authors:  S V Sharma; T Agatsuma; H Nakano
Journal:  Oncogene       Date:  1998-05       Impact factor: 9.867

Review 3.  Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy.

Authors:  David J Newman; Gordon M Cragg; Susan Holbeck; Edward A Sausville
Journal:  Curr Cancer Drug Targets       Date:  2002-12       Impact factor: 3.428

4.  Geldanamycin. I. Structure assignment.

Authors:  K Sasaki; K L Rinehart; G Slomp; M F Grostic; E C Olson
Journal:  J Am Chem Soc       Date:  1970-12-30       Impact factor: 15.419

5.  Synthesis of gerfelin and related analogous compounds.

Authors:  Md Sadequl Islam; Mitsuhiro Kitagawa; Masaya Imoto; Takeshi Kitahara; Hidenori Watanabe
Journal:  Biosci Biotechnol Biochem       Date:  2006-10-07       Impact factor: 2.043

6.  Search for Hsp90 inhibitors with potential anticancer activity: isolation and SAR studies of radicicol and monocillin I from two plant-associated fungi of the Sonoran desert.

Authors:  Thomas J Turbyville; E M Kithsiri Wijeratne; Manping X Liu; Anna M Burns; Christopher J Seliga; Libia A Luevano; Cynthia L David; Stanley H Faeth; Luke Whitesell; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2006-02       Impact factor: 4.050

7.  New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target.

Authors:  Zhi-Qiang Yang; Xudong Geng; David Solit; Christine A Pratilas; Neal Rosen; Samuel J Danishefsky
Journal:  J Am Chem Soc       Date:  2004-06-30       Impact factor: 15.419

8.  Screening of agents which convert 'transformed morphology' of Rous sarcoma virus-infected rat kidney cells to 'normal morphology': identification of an active agent as herbimycin and its inhibition of intracellular src kinase.

Authors:  Y Uehara; M Hori; T Takeuchi; H Umezawa
Journal:  Jpn J Cancer Res       Date:  1985-08

Review 9.  Development of purine-scaffold small molecule inhibitors of Hsp90.

Authors:  Gabriela Chiosis; Brian Lucas; Henri Huezo; David Solit; Andrea Basso; Neal Rosen
Journal:  Curr Cancer Drug Targets       Date:  2003-10       Impact factor: 3.428

Review 10.  The clinical applications of heat shock protein inhibitors in cancer - present and future.

Authors:  Udai Banerji; Ian Judson; Paul Workman
Journal:  Curr Cancer Drug Targets       Date:  2003-10       Impact factor: 3.428
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  2 in total

Review 1.  Macrocyclic inhibitors of hsp90.

Authors:  Victoria A Johnson; Erinprit K Singh; Lidia A Nazarova; Leslie D Alexander; Shelli R McAlpine
Journal:  Curr Top Med Chem       Date:  2010       Impact factor: 3.295

Review 2.  Natural and Synthetic Lactones Possessing Antitumor Activities.

Authors:  Younghoon Kim; Sandip Sengupta; Taebo Sim
Journal:  Int J Mol Sci       Date:  2021-01-21       Impact factor: 6.208
  2 in total

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