Literature DB >> 2144112

Purification and characterization of dinitrophenylglutathione ATPase of human erythrocytes and its expression in other tissues.

R Sharma1, S Gupta, S V Singh, R D Medh, H Ahmad, E F LaBelle, Y C Awasthi.   

Abstract

S-(2,4-dinitrophenyl)glutathione (Dnp-SG) ATPase of human erythrocytes has been purified to apparent homogeneity by affinity chromatography. In reduced denaturing gels, the subunit Mr value of Dnp-SG ATPase was found to be 38,000. Dinitrophenyl glutathione (Dnp-SG) stimulated the hydrolysis of ATP by the purified enzyme whereas oxidized glutathione (GSSG) did not, indicating that Dnp-SG and GSSG are transported from the erythrocytes by different transporters. Results of Western blot analysis using the antibodies against Dnp-SG ATPase subunits indicated that the enzyme was expressed in human liver, lung, placenta and pancreas.

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Year:  1990        PMID： 2144112     DOI： 10.1016/0006-291x(90)91370-8

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  10 in total

1.  A nucleotide-binding domain of porcine liver annexin VI. Proteolysis of annexin VI labelled with 8-azido-ATP, purification by affinity chromatography on ATP-agarose, and fluorescence studies.

Authors:  J Bandorowicz-Pikuła
Journal:  Mol Cell Biochem       Date:  1998-04       Impact factor: 3.396

2.  Pharmacogenetics of ABCB5, ABCC5 and RLIP76 and doxorubicin pharmacokinetics in Asian breast cancer patients.

Authors:  S Lal; N Sutiman; L L Ooi; Z W Wong; N S Wong; P C S Ang; B Chowbay
Journal:  Pharmacogenomics J       Date:  2016-03-15       Impact factor: 3.550

3.  RLIP76 regulates HIF-1 activity, VEGF expression and secretion in tumor cells, and secretome transactivation of endothelial cells.

Authors:  Seunghyung Lee; Lawrence E Goldfinger
Journal:  FASEB J       Date:  2014-06-13       Impact factor: 5.191

4.  ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.

Authors:  I Leier; G Jedlitschky; U Buchholz; M Center; S P Cole; R G Deeley; D Keppler
Journal:  Biochem J       Date:  1996-03-01       Impact factor: 3.857

5.  RALBP1/RLIP76 depletion in mice suppresses tumor growth by inhibiting tumor neovascularization.

Authors:  Seunghyung Lee; Jeremy G T Wurtzel; Sharad S Singhal; Sanjay Awasthi; Lawrence E Goldfinger
Journal:  Cancer Res       Date:  2012-08-17       Impact factor: 12.701

Review 6.  RLIP76 and Cancer.

Authors:  Sanjay Awasthi; Sharad S Singhal; Yogesh C Awasthi; Bryan Martin; Jung-Hee Woo; C Casey Cunningham; Arthur E Frankel
Journal:  Clin Cancer Res       Date:  2008-07-15       Impact factor: 12.531

Review 7.  RLIP76: a versatile transporter and an emerging target for cancer therapy.

Authors:  Rit Vatsyayan; Poorna Chandra Rao Lelsani; Sanjay Awasthi; Sharad S Singhal
Journal:  Biochem Pharmacol       Date:  2010-01-25       Impact factor: 5.858

8.  Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein.

Authors:  S Awasthi; S S Singhal; S K Srivastava; P Zimniak; K K Bajpai; M Saxena; R Sharma; S A Ziller; E P Frenkel; S V Singh
Journal:  J Clin Invest       Date:  1994-03       Impact factor: 14.808

9.  Emerging treatments in lung cancer - targeting the RLIP76 molecular transporter.

Authors:  Lawrence E Goldfinger; Seunghyung Lee
Journal:  Lung Cancer (Auckl)       Date:  2013

10.  RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer's Disease.

Authors:  Sanjay Awasthi; Ashly Hindle; Neha A Sawant; Mathew George; Murali Vijayan; Sudhir Kshirsagar; Hallie Morton; Lloyd E Bunquin; Philip T Palade; J Josh Lawrence; Hafiz Khan; Chhanda Bose; P Hemachandra Reddy; Sharda P Singh
Journal:  Cells       Date:  2021-11-10       Impact factor: 6.600
  10 in total

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