| Literature DB >> 21441024 |
Dominique Lesuisse1, Jacques Mauger, Conception Nemecek, Sébastien Maignan, Janine Boiziau, Greg Harlow, Augustin Hittinger, Swen Ruf, Hartmut Strobel, Anil Nair, Kurt Ritter, Jean-Luc Malleron, Anne Dagallier, Youssef El-Ahmad, Jean-Pierre Guilloteau, Houlfa Guizani, Hervé Bouchard, Corinne Venot.
Abstract
A new series of IGF-1R inhibitors related to hydantoins were identified from a lead originating from HTS. Their noncompetitive property as well as their slow binding characteristics provided a series of compounds with unique selectivity and excellent cellular activities.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21441024 DOI： 10.1016/j.bmcl.2011.03.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823