| Literature DB >> 21439820 |
Qingmei Hong1, Raman K Bakshi, Brenda L Palucki, Min K Park, Zhixiong Ye, Shuwen He, Patrick G Pollard, Iyassu K Sebhat, Jian Liu, Liangqin Guo, Doreen E Cashen, William J Martin, David H Weinberg, Tanya MacNeil, Rui Tang, Constantin Tamvakopoulos, Qianping Peng, Randy R Miller, Ralph A Stearns, Howard Y Chen, Airu S Chen, Alison M Strack, Tung M Fong, D Euan MacIntyre, Matthew J Wyvratt, Ravi P Nargund.
Abstract
We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21439820 DOI： 10.1016/j.bmcl.2011.02.090
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823