Literature DB >> 21438813

Diabetic dyslipidemia or 'diabetes lipidus'?

Diana Muačević-Katanec1, Zeljko Reiner.   

Abstract

Diabetes mellitus is one of the most important risk factors for cardiovascular diseases. The results of several studies have shown that achieving satisfactory glucoregulation results in a significant reduction in the incidence of microvascular and macrovascular complications, and cardiovascular mortality. However, the risk of the development of cardiovascular diseases is markedly increased in the presence of dyslipoproteinemia. Research has shown that hyperglycemia not only causes apoptosis of β-cells in the islets of Langerhans (glucotoxicity) but also determines the degree of accumulation of oxidized LDLs. On the other hand, dyslipoproteinemia itself has a toxic effect on β-cells, but only in the presence of increased blood glucose levels, thus increasing the risk of the development of cardiovascular diseases exponentially. As diabetes and the lipid metabolism disorder can be neither scrutinized nor treated separately, the authors query whether 'diabetes lipidus' would be a more appropriate term.

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Year:  2011        PMID: 21438813     DOI: 10.1586/erc.11.17

Source DB:  PubMed          Journal:  Expert Rev Cardiovasc Ther        ISSN: 1477-9072


  6 in total

1.  Comparison of Effectiveness and Safety of Add-on Therapy of Saroglitazar and Fenofibrate with Metformin in Indian Patients with Diabetic Dyslipidaemia.

Authors:  Arijit Ghosh; Pranab Kumar Sahana; Chanchal Das; Ananya Mandal; Nilanjan Sengupta
Journal:  J Clin Diagn Res       Date:  2016-03-01

2.  Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models.

Authors:  Mukul R Jain; Suresh R Giri; Chitrang Trivedi; Bibhuti Bhoi; Akshyaya Rath; Geeta Vanage; Purvi Vyas; Ramchandra Ranvir; Pankaj R Patel
Journal:  Pharmacol Res Perspect       Date:  2015-05-04

3.  Correlation Between Glycated Hemoglobin and Homa Indices in Type 2 Diabetes Mellitus: Prediction of Beta-Cell Function from Glycated Hemoglobin.

Authors:  Hussein Kadhem Al-Hakeim; Mohammed Saied Abdulzahra
Journal:  J Med Biochem       Date:  2015-03-03       Impact factor: 3.402

4.  Are diabetes mellitus and lipoprotein(a) independently or causally associated with an increased cardiovascular risk?

Authors:  Marija Vavlukis
Journal:  Anatol J Cardiol       Date:  2017-03       Impact factor: 1.596

5.  The association between blood glucose levels and lipids or lipid ratios in type 2 diabetes patients: A cross-sectional study.

Authors:  Liqun Wang; Ning Yan; Min Zhang; Ruiping Pan; Yuqi Dang; Yang Niu
Journal:  Front Endocrinol (Lausanne)       Date:  2022-09-06       Impact factor: 6.055

6.  The Association between Persistent Hypertriglyceridemia and the Risk of Diabetes Development: The Kangbuk Samsung Health Study.

Authors:  Yu Hyun Kwon; Seul Ki Kim; Jung Hwan Cho; Hyemi Kwon; Se Eun Park; Hyung Geun Oh; Cheol Young Park; Won Young Lee; Ki Won Oh; Sung Woo Park; Eun Jung Rhee
Journal:  Endocrinol Metab (Seoul)       Date:  2018-01-30
  6 in total

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